Understanding Rare Liver Conditions in Children
Official title: Advancing our Understanding of Rare Pediatric Liver Diseases
Funded at Children's Hosp of Philadelphia · NIH-11124874 · Data updated 2026-11-12
This effort brings together experts to learn more about rare liver conditions affecting children, aiming to find better ways to care for them.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2002 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $372,499 |
| NIH project number | 5U01DK062481-24 |
| Project ID | NIH-11124874 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is relevant for children aged 0-11 years old who have been diagnosed with rare cholestatic pediatric liver diseases, such as biliary atresia.
✕Less likely to help
Adults or individuals without these specific rare pediatric liver conditions would not directly benefit from this particular research opportunity.
What this research studies
For over twenty years, a network of hospitals has been working together to understand rare liver conditions in children. This collaboration has built a valuable database and collection of biological samples to help researchers. By continuing to work together, we hope to uncover the causes, natural progression, and best treatment options for these complex diseases. Our goal is to improve the quality and effectiveness of care for all children living with these conditions.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of rare pediatric liver diseases, resulting in more effective treatments and improved care for affected children.
How similar studies have gone: This effort builds upon twenty years of coordinated investigations by the Childhood Liver Disease Research Network, which has already advanced understanding of these disorders.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Loomes, Kathleen Mary — Children's Hosp of Philadelphia
- Study coordinator: Loomes, Kathleen Mary
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.