How chronic liver diseases connect with other long-term illnesses
The Association of Liver Disease With Other Systemic Diseases, Focus on Diseases Progression, Treatments, and Clinical Outcomes: Analyses From the Hospital Database of Buddhist Tzu Chi Medical Foundation
We will look back at hospital records to see if chronic liver diseases are linked with other systemic illnesses in adults who visited Tzu Chi gastroenterology clinics.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 15000 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Academic / other |
| Locations | 1 site (New Taipei City) |
| Trial ID | NCT04525833 on ClinicalTrials.gov |
What this trial studies
This is a retrospective observational analysis of electronic health records from the Buddhist Tzu Chi Medical Foundation hospital database. The project will identify patients with chronic liver conditions (hepatitis B, hepatitis C, alcoholic liver disease, fatty liver, cirrhosis, and hepatocellular carcinoma) and examine associations with other systemic diseases, disease progression, treatments, and outcomes. Investigators will extract diagnoses, comorbidities, laboratory data, and treatment histories and apply statistical methods to detect correlations and patterns. Results aim to clarify how liver dysfunction influences risks and prognosis in other organ systems and to identify high-risk patient groups.
Who should consider this trial
Good fit: Adults aged 18–99 with medical records from gastroenterology clinics at the Tzu Chi hospitals, particularly those with recorded chronic liver disease, are the intended population.
Not a fit: People under 18 or over 99, those without records at Tzu Chi hospitals, or individuals seeking new interventional treatments rather than record-based insights are unlikely to receive direct benefit.
Why it matters
Potential benefit: If successful, this work could help clinicians identify patients at higher risk of systemic complications and improve monitoring or preventative care.
How similar studies have performed: Previous observational studies have reported links between diabetes and liver disease and between liver disease and systemic outcomes, but comprehensive retrospective analyses across multiple liver conditions are still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Individuals who visited the gastroenterology clinics of the Tzu Chi Hospitals, Buddhist Tzu Chi Medical Foundation Exclusion Criteria: * Age younger than 18 or older than 99 years
Where this trial is running
New Taipei City
- Ching-Sheng Hsu — New Taipei City, Taiwan (Recruiting)
Study contacts
- Principal investigator: Ching-Sheng Hsu, Ph.D — Liver Diseases Research Center, Taipei Tzu Chi Hospital
- Study coordinator: Ching-Sheng Hsu, Ph.D
- Email: hsu.chingsheng@gmail.com
- Phone: 886-979239381
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.