Investigating circular RNAs in liver diseases
Circular RNAs in Cholestatic Liver Diseases
['FUNDING_R01'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-10898186
This study is looking at how certain tiny molecules in your body, called circular RNAs, might be linked to primary sclerosing cholangitis (PSC), a liver disease, to help find new ways to understand and treat the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-10898186 on ClinicalTrials.gov |
What this research studies
This research focuses on primary sclerosing cholangitis (PSC), a serious liver disease characterized by inflammation and fibrosis of the bile ducts. The study aims to explore the role of circular RNAs (circRNAs) and other noncoding RNAs in the disease process, utilizing advanced RNA sequencing and bioinformatics to identify specific circRNAs that may be involved in liver injury. By understanding how these molecules function, the research seeks to uncover potential biomarkers or therapeutic targets for PSC. Patients may be monitored for changes in circRNA expression related to their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with primary sclerosing cholangitis or related cholestatic liver diseases.
Not a fit: Patients with liver diseases not related to cholestasis or those without a diagnosis of PSC may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new diagnostic tools or treatments for patients suffering from cholestatic liver diseases.
How similar studies have performed: While the role of circRNAs in liver diseases is an emerging field, previous studies have shown promising results in understanding their functions in other conditions, indicating potential for success in this area.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHOU, HUIPING ROSE — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: ZHOU, HUIPING ROSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.