Condition

Liver Failure clinical trials and research

• 14Clinical trials
• 7NIH research projects
• 7Countries

Newest Liver Failure clinical trials

All recruiting trials (14)

• Predicting liver failure after major liver surgery using CT measurements and vascular shape changes

  Doctors are testing whether adding vascular deformation mapping to CT measurements can better predict liver failure after removing a large portion of the liver.

  Recruiting at 3 sites Minia University · Minya, Minya Governorate and 2 other locations · NCT07727759

• Liver transplant with TLI and ATG conditioning to try stopping or reducing immunosuppression

  This trial tests whether a conditioning regimen with Total Lymphoid Irradiation and Anti-Tthymocyte Globulin after a liver transplant can help patients stop or minimize their immunosuppressive drugs over time.

  Recruiting Phase 1/2 Stanford University · Stanford, California · NCT07634562

• New bioartificial liver for people with liver failure or small-for-size syndrome

  This trial will test a bioartificial liver using hepatocytes made from chemically induced pluripotent stem cells to see if it is safe and tolerated in people with liver failure or small-for-size syndrome.

  Recruiting Phase 1/2 Beijing Friendship Hospital · Beijing · NCT07312864

• CRISPR-edited donor liver transplant to reduce rejection

  This trial will try transplanting deceased-donor livers that have had key HLA genes removed with CRISPR to see if they cause less rejection in adults needing a liver transplant.

  Recruiting Phase 1/2 American Organ Transplant and Cancer Research Institute LLC · Beijing, Changping · NCT07053488

• Evaluating citrate anticoagulation in kidney treatment for liver failure patients

  This study is testing if using citrate anticoagulation during kidney treatment helps critically ill patients with liver failure and kidney injury recover better and live longer.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06908746

• Using mesenchymal stem cells for blood purification to treat liver failure

  This study is testing if using stem cells to clean the blood can help adults with liver failure feel better and improve their health.

  Recruiting Phase 1 Zhujiang Hospital · Guangzhou, Guangdong · NCT06904755

• Microbiota augmentation to restore healthy gut bacteria in hospitalized liver patients

  This trial will test whether giving defined groups of healthy gut bacteria is safe and can restore key gut metabolites in hospitalized adults with liver disease who have low fecal butyrate and deoxycholic acid.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT06871111

• Does removing more normal liver tissue raise the risk of liver failure after liver resection?

  This study tests whether the amount of normal liver removed (RNLV) helps predict liver failure after surgery in people with hepatocellular carcinoma or intrahepatic cholangiocarcinoma.

  Recruiting at 3 sites National Natural Science Foundation of China · Fujian, Shanghai Municipality and 2 other locations · NCT06366048

• Evaluating HepaCure for treating acute-on-chronic liver failure in Chinese patients

  This study is testing if a new liver support system called HepaCure, used with another treatment, can help Chinese patients with acute-on-chronic liver failure feel better compared to using the other treatment alone.

  Recruiting Phase 1/2 Hexaell Biotech Co., Ltd. · Beijing, Beijing Municipality · NCT05989958

• Registry for managing liver failure in Chinese patients

  This study is trying to create a database to better understand liver failure in Chinese patients, looking at their health details and how infections and muscle loss affect their recovery.

  Recruiting at 4 sites First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi and 13 other locations · NCT05740696

• Using empagliflozin to treat patients with cirrhosis and fluid retention

  This study tests whether empagliflozin, a diabetes medication, can help people with cirrhosis and fluid retention feel better by improving their body water levels and kidney function.

  Recruiting Phase 2 Yale University · New Haven, Connecticut · NCT05726032

• Treatment for liver failure caused by immune checkpoint inhibitors in liver cancer patients

  This study is testing a new artificial liver support system to see if it can help liver cancer patients with liver failure caused by certain cancer treatments feel better compared to standard care.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT05484908

• Fecal microbiota transplantation for patients with liver failure

  This study tests whether a treatment using healthy gut bacteria can help people with liver failure feel better and improve their overall health.

  Recruiting Ningbo Medical Center Lihuili Hospital · Ningbo, Zhejiang · NCT05170971

• Evaluating sacituzumab govitecan for advanced solid tumors in patients with liver impairment

  This study is testing a new cancer treatment called sacituzumab govitecan to see if it's safe and effective for people with advanced tumors who also have liver problems.

  Recruiting at 13 sites Phase 1 Gilead Sciences · Long Beach, California and 14 other locations · NCT04617522

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• SRXN1 and protein sulfinylation in drug-induced acute liver failure

  A study in people and models aims to understand how a liver toxin (acetaminophen) causes liver failure by oxidative stress and how SRXN1-related processes might help prevent or treat it.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11443985

• Understanding how CD8 T cells and liver macrophages interact to cause pediatric acute liver failure

  A mentoring-based research effort aims to understand how immune cells in the liver contribute to severe liver failure in children.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11415760

• Intestine-targeted LXR therapy to protect the liver in short gut syndrome

  This project will try an intestine-only drug that activates LXR to help children with short gut syndrome avoid liver damage.

  NIH research Washington University · Saint Louis, United States · NIH-11370663

• Pediatric Acute Liver Failure: Quieting the Immune System to Help Young Patients

  This grant tests immune-suppressing therapies to help children with acute liver failure by calming an overactive immune response.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11345696

• Investigating how a protein affects liver failure during sepsis

  This study is looking at how infections can suddenly worsen liver problems in people who already have liver issues, using a special mouse model to explore how certain proteins affect liver health, with the hope of finding better treatments for those affected.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11134516

• Investigating treatments for children with severe liver failure caused by immune responses

  This study is looking at new treatments for kids with Pediatric Acute Liver Failure, a serious condition where the liver stops working properly, to see if certain medications can help calm down the immune system and heal the liver, potentially avoiding the need for a liver transplant.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11109381

• Investigating how energy production in mitochondria affects liver health

  This study is looking at how problems with energy production in liver cells might affect conditions like nonalcoholic fatty liver disease and liver failure, using a special mouse model to help find new ways to treat these liver issues.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11023057

Related topics

Quick answers

How many Liver Failure clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in China (8 trials), United States (4 trials), France (1 trial), Italy (1 trial), Spain (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 4, Phase 1: 3, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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