Understanding Rare Pediatric Liver Diseases inChiLDReN network
Official title: Advancing our Understanding of Rare Pediatric Liver Diseases
Funded at Children's Hosp of Philadelphia · NIH-11337617 · Data updated 2026-11-12
A national network study aims to grow knowledge about rare childhood liver diseases by sharing data and samples to improve care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2002 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $372,498 |
| NIH project number | 5U01DK062481-25 |
| Project ID | NIH-11337617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children and adolescents with rare pediatric liver diseases studied by ChiLDReN (e.g., biliary atresia, bile duct obstruction, biliary stasis).
✕Less likely to help
Patients not enrolled in ChiLDReN-related studies or those without the specific conditions studied may see no direct benefit.
What this research studies
This project continues the ChiLDReN Childhood Liver Disease Research Network, focusing on kids with cholestatic liver diseases. It builds on two decades of collaboration to collect patient data, biospecimens, and genomic information to better understand disease paths and treatments. The work involves observational and interventional studies across multiple sites, plus ancillary studies and sharing findings to clinicians and families. The team at CHOP coordinates with other centers to advance science and translate it into better, faster care for affected children.
Why it matters
Potential benefit: If successful, the work could lead to clearer diagnosis, tailored treatments, and improved outcomes for children with rare liver diseases.
How similar studies have gone: Prior ChiLDReN work has established a durable database and biorepository, supporting ongoing discoveries in pediatric liver disease.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Loomes, Kathleen Mary — Children's Hosp of Philadelphia
- Study coordinator: Loomes, Kathleen Mary
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.