Molecular tricks of T cells in kids with chronic liver disease
Official title: Molecular mechanisms of T cell dysfunction in pediatric chronic cholestatic liver diseases
Funded at Baylor College of Medicine · NIH-11371829 · Data updated 2026-11-12
A training program to understand why T cells don’t work well in children with chronic liver disease and how bile acids might be causing the problem.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | July 2, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $167,165 |
| NIH project number | 1K08DK141907-01A1 |
| Project ID | NIH-11371829 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with chronic cholestatic liver diseases, particularly those undergoing or awaiting liver transplantation, who have immune dysfunction.
✕Less likely to help
Children without CSLD or without immune dysfunction may not directly benefit from this program.
What this research studies
This five-year program will explore how bile acids alter immune signals in children with chronic cholestatic liver diseases. The research will look at how vitamin D receptor pathways affect T cell function and susceptibility to infections before and after liver transplantation. The project combines lab studies with data from pediatric patients to identify mechanisms and potential points for intervention. The goal is to uncover actionable biology that could lead to better protection from infections for affected children.
Why it matters
Potential benefit: Better understanding of why immune dysfunction occurs in these children could guide future therapies to prevent infections and improve transplant outcomes.
How similar studies have gone: Preliminary studies in pediatric cohorts and mouse models support a link between bile acids and impaired T cell function, but pediatric CAID mechanisms remain to be clarified.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Mysore, Krupa R — Baylor College of Medicine
- Study coordinator: Mysore, Krupa R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.