General versus spinal anesthesia with local numbing for buccal mucosal graft urethroplasty
General Anesthesia Versus Spinal Anesthesia With Local Anesthetic Infiltration for Buccal Mucosal Graft in Urethroplasty: A Randomized Controlled Trial
This project will see if spinal anesthesia plus local numbing causes less mouth and overall postoperative pain than general anesthesia for adult men having urethroplasty with a buccal (cheek) graft.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 21 Years and up |
| Sex | Male |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Trial ID | NCT07074730 on ClinicalTrials.gov |
What this trial studies
Urethroplasty using a buccal mucosal graft repairs urethral strictures but commonly causes pain at the oral graft harvest site. This interventional comparison tests two anesthesia approaches—general anesthesia versus spinal anesthesia combined with local infiltration at the graft site—to compare postoperative pain and recovery. Eligible adult men (≥21 years, ASA I–II) scheduled for urethroplasty at a single center are enrolled, with exclusions for chronic analgesic use, substance abuse, inability to report pain, relevant allergies, or local infection. Study procedures and pain outcomes are collected at Tanta University, Tanta, El‑Gharbia.
Who should consider this trial
Good fit: Adult men aged 21 years or older with ASA physical status I–II who are scheduled for urethroplasty using a buccal mucosal graft and who meet the stated exclusion criteria may qualify.
Not a fit: Patients using chronic analgesics, with substance abuse, neuropsychiatric conditions preventing reliable pain reporting, allergies to local anesthetics or opioids, or infection at puncture sites are excluded and unlikely to benefit from this comparison.
Why it matters
Potential benefit: If successful, the spinal plus local infiltration approach could reduce oral graft‑site pain and improve early recovery compared with general anesthesia.
How similar studies have performed: Spinal anesthesia with local infiltration is widely used for lower‑body procedures and has shown reduced systemic complications and comparable pain control in other settings, but evidence specifically targeting buccal mucosal harvest pain is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male patient age ≥ 21 years. * American Society of Anesthesiologists (ASA) classification I-II. * Patient scheduled for urethroplasty. Exclusion Criteria: * Patients who are taking analgesics for chronic illness or have a history of substance abuse. * Patients who are unable to describe their postoperative pain (e.g., neuropsychiatric disorder). * Patients with known local anesthetics and opioid allergy. * Patients with infection at the site of the needle puncture.
Where this trial is running
Tanta, El-Gharbia
- Tanta University — Tanta, El-Gharbia, Egypt (Recruiting)
Study contacts
- Study coordinator: Aya Allah H Elbahy, Master
- Email: 3ed2318@gmail.com
- Phone: 00201098959739
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.