General versus spinal anesthesia with local numbing for buccal mucosal graft urethroplasty
Official title: General Anesthesia Versus Spinal Anesthesia With Local Anesthetic Infiltration for Buccal Mucosal Graft in Urethroplasty: A Randomized Controlled Trial
Run by Tanta University · NCT07074730 · Data updated 2026-11-12
This project will see if spinal anesthesia plus local numbing causes less mouth and overall postoperative pain than general anesthesia for adult men having urethroplasty with a buccal (cheek) graft.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years and up |
| Sex | Men only |
| Enrollment | 100 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta, El-Gharbia) |
| Status | Recruiting |
| Started | July 19, 2025 |
| Main results expected | March 1, 2027 |
| Study ends | March 1, 2027 |
| Registry record updated | July 22, 2025 |
| Trial ID | NCT07074730 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult men aged 21 years or older with ASA physical status I–II who are scheduled for urethroplasty using a buccal mucosal graft and who meet the stated exclusion criteria may qualify.
✕Probably not a fit
Patients using chronic analgesics, with substance abuse, neuropsychiatric conditions preventing reliable pain reporting, allergies to local anesthetics or opioids, or infection at puncture sites are excluded and unlikely to benefit from this comparison.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Urethroplasty using a buccal mucosal graft repairs urethral strictures but commonly causes pain at the oral graft harvest site. This interventional comparison tests two anesthesia approaches—general anesthesia versus spinal anesthesia combined with local infiltration at the graft site—to compare postoperative pain and recovery. Eligible adult men (≥21 years, ASA I–II) scheduled for urethroplasty at a single center are enrolled, with exclusions for chronic analgesic use, substance abuse, inability to report pain, relevant allergies, or local infection. Study procedures and pain outcomes are collected at Tanta University, Tanta, El‑Gharbia.
Why it matters
Potential benefit: If successful, the spinal plus local infiltration approach could reduce oral graft‑site pain and improve early recovery compared with general anesthesia.
How similar studies have gone: Spinal anesthesia with local infiltration is widely used for lower‑body procedures and has shown reduced systemic complications and comparable pain control in other settings, but evidence specifically targeting buccal mucosal harvest pain is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male patient age ≥ 21 years. * American Society of Anesthesiologists (ASA) classification I-II. * Patient scheduled for urethroplasty. Exclusion Criteria: * Patients who are taking analgesics for chronic illness or have a history of substance abuse. * Patients who are unable to describe their postoperative pain (e.g., neuropsychiatric disorder). * Patients with known local anesthetics and opioid allergy. * Patients with infection at the site of the needle puncture.
Where it's running
-
Tanta University
Tanta, El-Gharbia, Egypt Recruiting
Study contacts
- Study coordinator: Aya Allah H Elbahy, Master
- Email: 3ed2318@gmail.com
- Phone: 00201098959739
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.