Pain monitoring with ANI during rapid sequence induction
Official title: Nociception Assessment During Rapid Sequence Induction: A Prospective Observational Study of Practices and Complications - The NARSI Study
Run by Centre Hospitalier Princesse Grace · NCT07588165 · Data updated 2026-11-12
This study tests whether the Analgesia Nociception Index (ANI) can measure pain during rapid sequence induction in adults undergoing tracheal intubation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Centre Hospitalier Princesse Grace Academic / other |
| Locations | 1 site (Monaco) |
| Status | Recruiting |
| Started | May 21, 2026 |
| Main results expected | May 2028 |
| Study ends | May 2028 |
| Registry record updated | May 27, 2026 |
| Trial ID | NCT07588165 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) undergoing tracheal intubation after RSI in the visceral surgery operating room and monitored with ANI.
✕Probably not a fit
Patients not monitored with ANI or not undergoing RSI would not contribute data to ANI-based pain assessment.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a single-center prospective observational study in Monaco that describes how RSI affects nociception as measured by ANI in adults. Researchers will monitor ANI alongside standard anesthesia care to explore pain levels and early complications such as desaturation, hypotension, and regurgitation. Induction drugs are chosen by the treating anesthesiologist, and ANI monitoring uses non-invasive electrodes during the procedure.
Why it matters
Potential benefit: If ANI reliably reflects pain during RSI, clinicians could adjust analgesia in real time to improve patient comfort and safety.
How similar studies have gone: No prior studies have evaluated ANI during RSI, so this is a novel investigation with exploratory potential.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \>= 18 years * Patient requiring tracheal intubation after rapid sequence induction in the visceral surgery operating room * Pain monitoring by Analgesia Nociception Index (ANI) as part of general anesthesia Exclusion Criteria: * Patient with atrial fibrillation at the time of intubation following rapid sequence induction * Patient on long-term beta-blocker therapy
Where it's running
-
Centre Hospitalier Princesse Grace
Monaco, Monaco Recruiting
Study contacts
- Principal investigator: Remy WIDEHEM, MD — Centre Hospitalier Princesse Grace
- Study coordinator: Remy WIDEHEM
- Email: remy.widehem@chpg.mc
- Phone: +377 97 98 99 00
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.