Clinical trial Recruiting at 1 site Observational Ages 18 and up

Pain monitoring with ANI during rapid sequence induction

Official title: Nociception Assessment During Rapid Sequence Induction: A Prospective Observational Study of Practices and Complications - The NARSI Study

Run by Centre Hospitalier Princesse Grace · NCT07588165 · Data updated 2026-11-12

This study tests whether the Analgesia Nociception Index (ANI) can measure pain during rapid sequence induction in adults undergoing tracheal intubation.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment150 (estimated)
SponsorCentre Hospitalier Princesse Grace
Academic / other
Locations1 site (Monaco)
StatusRecruiting
StartedMay 21, 2026
Main results expectedMay 2028
Study endsMay 2028
Registry record updatedMay 27, 2026
Trial IDNCT07588165 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) undergoing tracheal intubation after RSI in the visceral surgery operating room and monitored with ANI.

Probably not a fit

Patients not monitored with ANI or not undergoing RSI would not contribute data to ANI-based pain assessment.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center prospective observational study in Monaco that describes how RSI affects nociception as measured by ANI in adults. Researchers will monitor ANI alongside standard anesthesia care to explore pain levels and early complications such as desaturation, hypotension, and regurgitation. Induction drugs are chosen by the treating anesthesiologist, and ANI monitoring uses non-invasive electrodes during the procedure.

Why it matters

Potential benefit: If ANI reliably reflects pain during RSI, clinicians could adjust analgesia in real time to improve patient comfort and safety.

How similar studies have gone: No prior studies have evaluated ANI during RSI, so this is a novel investigation with exploratory potential.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age \>= 18 years
* Patient requiring tracheal intubation after rapid sequence induction in the visceral surgery operating room
* Pain monitoring by Analgesia Nociception Index (ANI) as part of general anesthesia

Exclusion Criteria:

* Patient with atrial fibrillation at the time of intubation following rapid sequence induction
* Patient on long-term beta-blocker therapy

Where it's running

  • Centre Hospitalier Princesse Grace
    Monaco, Monaco
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.