Frontal EEG Changes During Anesthesia in People With Obesity vs. Normal Weight

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study compares how frontal EEG signals change around loss of consciousness during propofol anesthesia in adults with obesity and those with normal weight. Researchers will analyze spectral features such as alpha and delta power and the alpha/delta ratio, as well as frontal alpha asymmetry, throughout the intraoperative period. Anesthetic care is given by routine clinical practice, not dictated by the study team. Continuous frontal EEG monitoring (SedLine) is required, and participants are grouped by BMI: 18.5–24.9 for normal weight and ≥30 for obesity. The study excludes individuals with certain neurological or forehead-accessibility conditions that could affect EEG data quality.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18-65 years
* Scheduled for elective surgery under general anesthesia
* American Society of Anesthesiologists (ASA) physical status I-III
* General anesthesia induction performed with propofol
* Availability of continuous frontal EEG monitoring (SedLine) during anesthesia
* BMI 18.5-24.9 kg/m² for the normal-weight group or BMI ≥30 kg/m² for the obesity group
* Ability to provide written informed consent

Exclusion Criteria:

* \- BMI 25.0-29.9 kg/m²
* History of epilepsy or seizure disorder
* Known major neurological disease that may affect EEG activity
* Altered level of consciousness before anesthesia
* Regular use of antiepileptic medications or other drugs known to substantially affect EEG activity
* Emergency surgery
* Pregnancy
* Skin lesions, infection, or other conditions of the forehead preventing appropriate placement of the EEG sensor
* Inability to obtain an adequate-quality EEG recording because of technical failure or excessive artifacts
* Requirement for substantial deviation from the planned routine anesthetic management that prevents standardized EEG assessment
* Refusal to participate or inability to provide written informed consent

Where it's running

• Düzce University Research and Application Hospital
  Düzce, Düzce, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: gizem demir şenoğlu, ass. prof
• Email: gizem123demir@hotmail.com
• Phone: 05059313588

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.