Remimazolam versus Midazolam for anesthesia induction in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational cohort study records real-world use of two benzodiazepine sedatives—remimazolam and midazolam—during induction of general anesthesia in elderly patients. Patients are grouped by the sedative actually used, with anesthesiologists selecting the agent per routine practice. Data collected include demographics, medical history, intraoperative variables, hemodynamic events, drug doses, fluid balance, blood loss, and recovery outcomes. Propensity score methods will be applied to adjust for confounding and compare outcomes. The study does not modify standard care and aims to characterize safety and hemodynamic performance in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 65 years or older.
2. Scheduled for elective non-cardiac surgery under general anesthesia.
3. American Society of Anesthesiologists physical status I to IV.
4. Planned airway management with tracheal intubation or a laryngeal mask airway.
5. Written informed consent provided by the participant or the participant's legally authorized representative.

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Exclusion Criteria:

1. Long-term preoperative benzodiazepine use.
2. Known allergy or contraindication to benzodiazepines, flumazenil, opioids, naloxone, or related drugs.
3. History of drug abuse or alcoholism within the past 2 years.
4. No preoperative cognitive assessment available.
5. Preoperative cognitive impairment, defined as a Mini-Mental State 6.Examination score less than 18.

7.Refusal to provide informed consent.

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Where it's running

• The Second Affiliated Hospital of Zhejiang University School of Medicin
  Hangzhou, China Recruiting

Study contacts

• Study coordinator: min Yan, doctor
• Email: zryanmin@zju.edu.cn
• Phone: +86 13757118632

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.