Safer muscle relaxant and reversal choice during anesthesia for people with chronic kidney disease
Official title: Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease
Run by The University of Texas Medical Branch, Galveston · NCT07203287 · Data updated 2026-11-12
This trial will try to see if using cisatracurium with neostigmine leads to fewer breathing problems after surgery than using rocuronium with sugammadex in adults who have chronic kidney disease.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 490 (estimated) |
| Sponsor | The University of Texas Medical Branch, Galveston Academic / other |
| Locations | 1 site (Galveston, Texas) |
| Status | Recruiting |
| Started | August 26, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | August 26, 2027 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT07203287 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with chronic kidney disease (reduced GFR) scheduled for elective surgery requiring general anesthesia and endotracheal intubation, who are not on dialysis and can give informed consent, are ideal candidates.
✕Probably not a fit
Patients with end-stage renal disease, those requiring dialysis, renal transplant recipients, pregnant women, incarcerated individuals, emergency surgeries, or those needing postoperative intubation are excluded and therefore will not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with chronic kidney disease undergoing elective surgery with general anesthesia are randomized to receive either rocuronium with sugammadex or cisatracurium with neostigmine as the neuromuscular blocker and reversal regimen. Both approaches are current standard-of-care options and reversal will be performed and documented per protocol. Patients are followed for up to seven days after surgery for postoperative pulmonary complications such as atelectasis, hypoxia, respiratory failure, pneumonia, and pneumothorax. The study excludes patients with end-stage renal disease, those on dialysis, transplant recipients, pregnant patients, and emergency procedures.
Why it matters
Potential benefit: If successful, the results could identify a safer anesthesia drug combination that reduces postoperative breathing complications in people with chronic kidney disease.
How similar studies have gone: Both drug combinations are widely used in practice, but direct randomized comparisons focused on postoperative pulmonary outcomes specifically in chronic kidney disease patients are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * The subject is able and willing to provide and sign informed consent * The subject must be between 18 and 80 years of age * The subject should have chronic kidney disease as defined by glomerular filtration rate * The surgery must require general anesthesia with endotracheal intubation and neuromuscular blockade Exclusion Criteria: * Any patient under the age of 18 * Any patient over the age of 80 * Any patient with end stage renal disease * Any patient requiring dialysis * Patients presenting for Renal Transplantation * Pregnant Female * Any patient in the correctional system * Urgent or Emergent procedure * The surgery requires intubation post-operatively * Documented allergy to Rocuronium, Sugammadex, Cisatracurium or Neostigmine
Where it's running
-
University of Texas Medical Branch
Galveston, Texas, United States Recruiting
Study contacts
- Principal investigator: Michael Kinsky, MD — University of Texas
- Study coordinator: Michael Kinsky, MD
- Email: mkinsky@utmb.edu
- Phone: 409-772-1011
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.