Pre-op ultrasound of the IVC and aorta to predict blood pressure drops after anesthesia
Official title: Preoperative Evaluation of IVC Collapsibility Index and Caval Aorta Index for Prediction of Hypotension After Induction of General Anesthesia in Patients Undergoing Craniotomy Surgeries
Run by Ain Shams University · NCT07399093 · Data updated 2026-11-12
We will see if simple pre-op ultrasound measurements of the IVC collapsibility and the caval–aorta index can predict which adults having elective craniotomy will have a drop in blood pressure when general anesthesia is started.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | Ain Shams University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | January 14, 2024 |
| Main results expected | March 1, 2026 |
| Study ends | March 1, 2026 |
| Registry record updated | February 10, 2026 |
| Trial ID | NCT07399093 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–40 who are ASA I–II, BMI under 40, fasted per guidelines, and scheduled for elective craniotomy are the intended participants.
✕Probably not a fit
Patients with existing cardiac disease or hypertension, those taking blood‑pressure–altering medications, pregnant patients, emergency surgery cases, or those outside the age/BMI criteria are unlikely to benefit from these specific findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will enroll adults (18–40 years, ASA I–II, BMI <40) scheduled for elective craniotomy at Ain Shams University Hospitals. Investigators will perform bedside ultrasound before induction to measure inferior vena cava collapsibility index (IVCCI) and the caval–aorta index, with repeat measurements to test repeatability and reproducibility. Blood pressure and hemodynamic data will be recorded after induction to document hypotension using predefined criteria. The study will compare the ultrasound indices to post‑induction blood pressure changes to determine their predictive accuracy.
Why it matters
Potential benefit: If successful, clinicians could use a quick bedside ultrasound to identify patients at higher risk of post‑induction hypotension and tailor fluids or medications to reduce that risk.
How similar studies have gone: Prior studies and guideline statements support IVCCI as a noninvasive marker of volume status, but results have been mixed across different populations so its ability to predict post‑induction hypotension is not yet settled.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 40 years. * Both sexes. * Body Mass Index\< 40 kg/m². * American Society of Anesthesiologists (ASA) physical status I, II. * Fasted according to the ASA guidelines: 2 hours for clear fluids, 6 hours after light meal, 8 hours after a full meal with high calorie or fat content. * Scheduled for elective craniotomy surgeries before induction of general anesthesia. Exclusion Criteria: * Current or recent pregnancy (within 3 months). * Pre-existing cardiac disease or hypertension. * On medications affecting blood pressure \[Beta-blockers (BBs) and calcium channel blockers (CCBs)\] . * Refusing to undergo the study.
Where it's running
-
Ain Shams University Hospitals
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Verina F Zaref, MSc
- Email: verina.fares@med.asu.edu.eg
- Phone: 00201098858385
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.