Validate the MASCAN score for predicting difficult facemask ventilation
Official title: External Validation of the MASCAN Score for the Classification of Difficult Mask Ventilation
Run by Universitätsklinikum Hamburg-Eppendorf · NCT07114549 · Data updated 2026-11-12
This study will see if the MASCAN score can predict difficult facemask ventilation in adults having general anesthesia and whether factors like timing of muscle relaxants, manual versus controlled ventilation, and capnography readings change its accuracy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 926 (estimated) |
| Sponsor | Universitätsklinikum Hamburg-Eppendorf Academic / other |
| Locations | 1 site (Hamburg, Free and Hanseatic City of Hamburg) |
| Status | Recruiting |
| Started | August 8, 2025 |
| Main results expected | December 2025 |
| Study ends | January 2026 |
| Registry record updated | August 21, 2025 |
| Trial ID | NCT07114549 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18) scheduled for surgery with general anesthesia who will require facemask ventilation and tracheal intubation and can give informed consent are ideal candidates.
✕Probably not a fit
People who are pregnant or breastfeeding, require rapid-sequence induction, are planned for awake intubation, or do not require facemask ventilation are unlikely to benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational external validation of the MASCAN score in adults undergoing general anesthesia who require facemask ventilation and tracheal intubation. Study staff will record MASCAN components and real-world ventilation practices, including timing of neuromuscular blocking agents and whether mask ventilation is manual or controlled. Investigators will also collect visual assessments of the capnography waveform and compare first-attempt intubation success as reported by the airway operator versus an independent observer. No experimental interventions are applied; the study observes routine clinical care at a single center.
Why it matters
Potential benefit: If successful, the MASCAN score could help clinicians anticipate difficult facemask ventilation and prepare appropriate airway management to reduce complications.
How similar studies have gone: The MASCAN score was developed prospectively but has limited external validation so far, while other airway-prediction tools have shown mixed success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who are scheduled for surgery with general anesthesia and require facemask ventilation and tracheal intubation after induction of anesthesia * Patients aged 18 years or older * Provided informed consent Exclusion Criteria: * Pregnant or breastfeeding woman * Required rapid sequence induction or other contraindications for facemask ventilation * Planned awake tracheal intubation * No consent given
Where it's running
-
University Medical Center Hamburg-Eppendorf
Hamburg, Free and Hanseatic City of Hamburg, Germany Recruiting
Study contacts
- Study coordinator: Martin Petzoldt, MD
- Email: m.petzoldt@uke.de
- Phone: +49 152 2281 5932
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Hyperangulated vs. Macintosh blades for obstetric intubation
This study tests whether a hyperangulated blade or a Macintosh-style blade helps obstetric patients get an endotracheal tube placement more safely during cesarean deliveries under general anesthesia.
-
Comparing two airway devices for minor urological procedures under general anesthesia
This study is testing which of two airway devices, the iGel or the Protector, works better and safer for adults undergoing minor urological procedures with general anesthesia.
-
Frontal EEG Changes During Anesthesia in People With Obesity vs. Normal Weight
This study tests whether frontal brain activity patterns during anesthesia differ between adults with obesity and those of normal weight.
-
Ultrasound Measurements and Age-Related Anatomy to Guide LMA Placement
This study tests whether ultrasound measurements of the upper airway and age-related anatomy affect how easily and accurately a laryngeal mask is placed in young adults and older adults.
-
AI-assisted ultrasound check for LMA placement in adults
A prospective study tests if artificial intelligence using ultrasound images can determine whether a laryngeal mask airway is placed correctly in adults having surgery.
-
Remimazolam versus Midazolam for anesthesia induction in older adults
This observational study compares remimazolam and midazolam when inducing anesthesia in people aged 65 and older undergoing elective non-cardiac surgery to see which provides better stability and safety.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.