Creating new technologies to better manage pain during and after surgery
Official title: Developing Active Stimulation and Monitoring Technologies to Optimize Pain and Nociception Management During Regional Anesthesia, General Anesthesia, and Post-Operative Care
Funded at Pascall Systems, Incorporated · NIH-11160369 · Data updated 2026-11-12
This study is testing new ways to help doctors better manage pain during and after surgery, especially for patients getting regional anesthesia, so they can provide more personalized care and help prevent long-term pain and reliance on pain medications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pascall Systems, Incorporated NIH-funded |
| Lab location | 1 site (Boston, UNITED STATES) |
| Project start | September 19, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,208,662 |
| NIH project number | 4R42NS129395-02 |
| Project ID | NIH-11160369 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing surgical procedures that require anesthesia, particularly those at risk for acute post-operative pain.
✕Less likely to help
Patients who are not undergoing surgery or those who do not require anesthesia may not benefit from this research.
What this research studies
This research focuses on developing innovative technologies to monitor and manage pain during surgical procedures and in the post-operative period. By utilizing event-related potentials (ERPs), the project aims to provide anesthesiologists with real-time data on the effectiveness of pain management strategies, particularly in patients receiving regional anesthesia. This approach seeks to reduce the reliance on guesswork in pain management, ultimately improving patient outcomes and reducing the risk of chronic pain and opioid dependence. The technology will assess pain responses to stimuli, allowing for more tailored analgesic therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain management strategies, reducing the incidence of chronic pain and opioid dependence in surgical patients.
How similar studies have gone: While the approach of using ERPs for pain assessment is innovative, similar technologies have shown promise in other areas of pain management, indicating potential for success.
Where this research is happening
-
Pascall Systems, Incorporated
Boston, United States Active
Researchers
- Principal investigator: Le Mau, Tuan — Pascall Systems, Incorporated
- Study coordinator: Le Mau, Tuan
Related research
Other NIH-funded projects on the same topics.
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Active monitoring to guide pain and nerve block care during surgery and recovery
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-
A device to detect hidden pain signals during and after surgery
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How common anesthetics affect Alzheimer-related brain changes in men and women
This project looks at whether common anesthetics cause Alzheimer-related brain changes differently in men and women and whether sex hormones might protect older adults who need surgery.
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Neural signals in surgical wound healing and how regional anesthesia changes them
Researchers are studying how nerve signals and the immune system interact after surgery and how regional anesthesia might improve healing.
-
Understanding how people wake up from general anesthesia
This grant studies why people wake up from anesthesia and what happens in the brain when they emerge, aiming to reduce confusion and agitation after surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.