Sublingual caffeine to shorten recovery and reduce agitation after general anesthesia in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study gives eligible patients either sublingual caffeine citrate or a matching placebo around the time of emergence from general anesthesia to compare recovery times and the incidence of postoperative agitation. Participants are adults aged 65 or older with ASA physical status II scheduled for elective ophthalmology procedures under general anesthesia, and those with significant cardiac disease, cognitive impairment, seizure disorders, substance abuse, or very long or emergency surgeries are excluded. Caffeine is a CNS stimulant that blocks adenosine A1/A2A receptors and has been shown to speed emergence from anesthesia in some settings, providing the biological rationale for the intervention. The study measures time to recovery and occurrence of agitation/delirium in the immediate postoperative period to determine if sublingual caffeine offers clinical benefit in this vulnerable population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 65 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status II.
* Scheduled for elective ophthalmology surgery under general anesthesia.

Exclusion Criteria:

* History of severe cardiac arrhythmias or uncontrolled hypertension.
* ASA III patients were excluded to reduce the risk of adverse events in elderly patients with severe systemic diseases.
* Known allergy or hypersensitivity to caffeine.
* Pre-existing cognitive impairment or dementia (All patients will undergo preoperative cognitive screening using the online Mini-Cog test or Montreal Cognitive Assessment \[MoCA\]).
* History of seizures or epilepsy.
* History of alcohol or drug abuse.
* Chronic use of CNS stimulants or sedatives.
* Emergency surgeries.
* Prolonged procedures for more than 3 hours.

Where it's running

• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Ghada A Sherif, MD
• Email: drghadasherif@gmail.com
• Phone: 00201006153615

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.