Anesthesia choice for mechanical thrombectomy in ischemic stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized study compares two anesthesia approaches—general anesthesia with airway control versus procedural sedation with spontaneous breathing—during mechanical thrombectomy for anterior circulation ischemic stroke. The goal is to see which approach leads to better functional outcomes, measured by the modified Rankin Scale at 3 months, while considering safety and procedure performance. Prior data from small European trials suggested possible advantages for GA, but results were inconclusive, prompting a larger, multicenter comparison. The study involves adult patients eligible for thrombectomy and requires an anesthesia team to manage sedation and airway as appropriate. Primary endpoints focus on functional independence after stroke, with secondary considerations including peri-procedural complications and hemodynamic stability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Acute ischemic stroke with an occlusion of the intracranial internal carotid artery and/or the proximal middle cerebral artery (M1-M2) with or without association of extracranial occlusion of the cervical internal carotid artery (tandem lesion)
* Eligible for mechanical thrombectomy according to international guidelines
* Informed and signed consent of patient, or if he is unable to consent the consent of patient's relative or emergency procedure in the absence of relative
* National health insurance

Exclusion Criteria:

* Coma or altered vigilance defined as a score ≥ 2 on the level of consciousness 1A subscale of the NIHSS
* Premorbid disability defined as a mRS \> 2
* Posterior circulation stroke
* Associated cerebral hemorrhage
* Stroke complicating another acute illness or postoperative stroke
* Emesis at arrival in angiosuite
* Allergy to anesthetic medication
* Pregnant or breast-feeding women
* Adult under the protection of the law

Where it's running

• CHU de Clermont-Ferrand
  Clermont-Ferrand, France Recruiting
• Le centre hospitalier universitaire de Lille
  Lille, France Recruiting
• Les Hospices Civils de Lyon
  Lyon, France Recruiting
• L'Assistance Publique - Hôpitaux de Marseille
  Marseille, France Recruiting
• Le Centre Hospitalier Universitaire de Nantes
  Nantes, France Recruiting
• L'Assistance Publique - Hôpitaux de Paris
  Paris, France Recruiting

Study contacts

• Principal investigator: Russell CHABANNE — University Hospital, Clermont-Ferrand
• Study coordinator: Lise Laclautre
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: 334.73.754.963

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.