Improving anesthesia management for elderly patients with Alzheimer's and related dementias
Developing an Elderly Patient-Specific, Accurate, Intuitive and Highly Interpretable System for Unconsciousness Management in General Anesthesia Using PASCALL FDA-Cleared Intraoperative EEG Monitor
This study is looking to make general anesthesia safer and more effective for older adults, especially those with Alzheimer's and similar conditions, by creating a smart monitoring system that helps doctors give just the right amount of anesthesia during surgery.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pascall Systems, Incorporated NIH-funded |
| Lab location | 1 site (Boston, UNITED STATES) |
| Project ID | NIH-11008566 on NIH RePORTER |
What this research studies
This research focuses on enhancing the safety and effectiveness of general anesthesia for elderly patients, particularly those with Alzheimer's disease and related dementias. It aims to develop a personalized monitoring system that uses advanced EEG technology to accurately assess brain activity during anesthesia. By utilizing specific brain state markers and a responsive algorithm, the system will help anesthesiologists tailor drug dosing to maintain optimal unconsciousness levels, reducing the risk of over-sedation and post-operative complications. The study will specifically target patients receiving propofol, a commonly used anesthetic.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly patients aged 65 and older, particularly those diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients who are not elderly or do not have Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of post-operative delirium in elderly patients undergoing surgery.
How similar studies have performed: Previous research has shown promise in using EEG monitoring for anesthesia management, indicating that this approach could lead to significant advancements in patient care.
Where this research is happening
Boston, UNITED STATES
- Pascall Systems, Incorporated — Boston, United States (Active)
Researchers
- Principal investigator: Le Mau, Tuan — Pascall Systems, Incorporated
- Study coordinator: Le Mau, Tuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.