Personalized oxygen therapy for cancer patients with shortness of breath
Official title: Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology
Run by M.D. Anderson Cancer Center · NCT06336642 · Data updated 2026-11-12
This study is testing a new personalized oxygen therapy to see if it helps hospitalized cancer patients with shortness of breath feel better compared to standard care.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | M.D. Anderson Cancer Center Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | June 11, 2024 |
| Main results expected | March 31, 2030 |
| Study ends | March 31, 2032 |
| Registry record updated | September 24, 2026 |
| Trial ID | NCT06336642 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 or older with advanced cancer experiencing moderate to severe dyspnea.
✕Probably not a fit
Patients with severe hypoxemia, respiratory failure, or those requiring intensive care are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the effects of Structured Personalized Oxygen and Supportive Therapies for Dyspnea in Oncology (SPOT-ON) on alleviating shortness of breath in hospitalized cancer patients. It aims to compare the effectiveness of SPOT-ON against Enhanced Usual Care in both hypoxemic and non-hypoxemic patients. The study will assess changes in dyspnea intensity and other patient outcomes over a 72-hour period, while also exploring factors influencing patient responses to the intervention.
Why it matters
Potential benefit: If successful, this approach could significantly improve the management of dyspnea in cancer patients, enhancing their quality of life.
How similar studies have gone: Previous studies have shown promise in using personalized oxygen therapies for dyspnea management, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of cancer * Age 18 or older. * Admitted to a medical floor. * Dyspnea intensity at rest of at least 4 on a 0-10-point NRS (where 0 = none, 10 = worst). * Speak English or Spanish. Exclusion Criteria: * Hemodynamic instability requiring active Merit Team or ICU team involvement. * Delirium as per clinical team's assessment in the Electronic Health Record (EHR). * Severe hypoxemia (SpO2 \< 90% despite supplemental oxygen of up to 6 L/min). * Continuous positive airway pressure (CPAP) use for obstructive sleep apnea, actively using \>10 hours a day. * Respiratory failure necessitating mechanical ventilation (i.e., HFNC or NIV), and planned thoracentesis within 72 hours of enrollment. * Patients with known pregnancy.
Where it's running
-
MD Anderson Cancer Center
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: David Hui, MD — M.D. Anderson Cancer Center
- Study coordinator: David Hui, MD
- Email: dhui@mdanderson.org
- Phone: (713) 792-6258
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.