Normal lung and heart function references for healthy US veterans who served in Southwest Asia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will recruit 200 age- and gender-matched healthy veterans with no history of exposure to airborne hazards. Participants will undergo comprehensive evaluations aligned with the PDCEN Core Clinical Evaluation, including questionnaires, pulmonary function testing, oscillometry, CPET with maximum effort, echo, chest CT, and biomarker analysis. The goal is to establish baseline reference values for lung and heart function in this specific population, while also capturing childhood health and fitness data. Data will be collected to compare against veterans with exposure-related conditions and to inform future assessments of cardiopulmonary health in this group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 24-68
* U.S. Veteran deployed between 1990 to 2021
* No respiratory complaints (defined as modified Medical Research Council score = 0)
* No use of respiratory medications

Exclusion Criteria:

* Non-English speaking
* Pregnancy
* BMI\>35 Kg/m2
* Tobacco smoking within prior year
* Lifetime tobacco smoking of \>5 pack-years
* Current inhaled cannabis use (any modality) \>2x weekly
* Prior inhaled cannabis uses exceeding 2x weekly within the prior year
* Illicit drug use (other than cannabis)
* No prior or current major organ disease, including but not limited to:

  * Neuromuscular weakness
  * History of malignancy (other than non-melanoma skin cancer)-- HIV/AIDS
  * Autoimmune disease
  * Solid-organ or hematopoietic stem cell transplant
  * Cardiovascular disease (other than mild HTN; \< 140/90; controlled on 2 or less medications)

    * Poorly-controlled HTN (SBP\>140 or DBP\>90 or use of more than 2 anti-hypertensive medications)
    * Any history of congestive heart failure (CHF, either HFpEF or HFrEF)
    * Any history of arrythmia (including atrial fibrillation)

Where it's running

• University of California San Francisco
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Mehrdad Arjomandi, MD — University of California, San Francisco
• Study coordinator: Mehrdad Arjomandi, MD
• Email: mehrdad.arjomandi@ucsf.edu
• Phone: 415-221-4810

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.