Identifying new treatments for dilated cardiomyopathy using microRNA
Using miRNA to identify new therapeutic pathways for dilated cardiomyopathy
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11127039
This study is looking at how tiny molecules called microRNAs affect dilated cardiomyopathy, a heart condition that can lead to heart failure, to find new ways to help people with this disease feel better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11127039 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microRNA in dilated cardiomyopathy (DCM), a serious heart condition that can lead to heart failure. The project aims to understand how specific microRNAs can influence the disease and potentially serve as targets for new therapies. By studying induced pluripotent stem cell-derived cardiomyocytes, the researchers will explore the mechanisms by which these microRNAs operate and their effects on heart function. The ultimate goal is to translate these findings into effective treatment strategies for patients suffering from DCM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those with specific genetic variants associated with the condition.
Not a fit: Patients with heart conditions unrelated to dilated cardiomyopathy or those without identifiable genetic variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients with dilated cardiomyopathy, improving their heart function and overall health.
How similar studies have performed: Previous research has shown promise in using microRNA as therapeutic targets in other heart conditions, suggesting a potential for success in this novel approach.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRIGANTI, FRANCESCA — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: BRIGANTI, FRANCESCA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene