Identifying new treatments for dilated cardiomyopathy using microRNA
Official title: Using miRNA to identify new therapeutic pathways for dilated cardiomyopathy
Funded at University of California, San Diego · NIH-11127039 · Data updated 2026-11-12
This study is looking at how tiny molecules called microRNAs affect dilated cardiomyopathy, a heart condition that can lead to heart failure, to find new ways to help people with this disease feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 12, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $248,999 |
| NIH project number | 4R00HL165099-02 |
| Project ID | NIH-11127039 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those with specific genetic variants associated with the condition.
✕Less likely to help
Patients with heart conditions unrelated to dilated cardiomyopathy or those without identifiable genetic variants may not benefit from this research.
What this research studies
This research investigates the role of microRNA in dilated cardiomyopathy (DCM), a serious heart condition that can lead to heart failure. The project aims to understand how specific microRNAs can influence the disease and potentially serve as targets for new therapies. By studying induced pluripotent stem cell-derived cardiomyocytes, the researchers will explore the mechanisms by which these microRNAs operate and their effects on heart function. The ultimate goal is to translate these findings into effective treatment strategies for patients suffering from DCM.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients with dilated cardiomyopathy, improving their heart function and overall health.
How similar studies have gone: Previous research has shown promise in using microRNA as therapeutic targets in other heart conditions, suggesting a potential for success in this novel approach.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Briganti, Francesca — University of California, San Diego
- Study coordinator: Briganti, Francesca
Related research
Other NIH-funded projects on the same topics.
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Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data
A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.
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Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it
This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.
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Unlocking how rare genetic changes cause dilated cardiomyopathy
A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.
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Role of Lmod2 in heart muscle and dilated cardiomyopathy
This NIH grant explores how a heart-specific protein (Lmod2) helps heart cells contract properly and how its problems can cause dilated cardiomyopathy in infants and children.
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Targeting DNA Damage Pathways in LMNA-Related Heart Disease
A study to understand how damaged DNA and inflammatory signals contribute to dilated cardiomyopathy caused by LMNA mutations and explore therapies that can protect the heart.
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Using miRNA to find new treatment paths for dilated cardiomyopathy
Researchers are studying heart-muscle disease (dilated cardiomyopathy) to discover miRNA-based clues that could lead to targeted therapies for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.