Condition

Cardiotoxicity clinical trials and research

• 24Clinical trials
• 78NIH research projects
• 1New in 30 days
• 18Countries

Newest Cardiotoxicity clinical trials

All recruiting trials (24)

• 3D Heart Strain to Detect Early Cardiotoxicity in Cancer Therapy

  This study tests whether 3D echocardiography can detect early heart damage from cancer treatments like anthracyclines or HER2-targeted therapy better than standard 2D methods.

  Recruiting Region Skane · Lund, Skåne County · NCT07916337

• Radiation-related heart damage in locally advanced NSCLC tested with PET-CT

  This study tests whether PET-CT imaging with 18F-Flurpiridaz can detect early radiation-related heart damage in adults with locally advanced non-small cell lung cancer receiving standard chemoradiation.

  Recruiting Phase 2 Indiana University · Indianapolis, Indiana · NCT07761910

• Pharmacogenomic panel to predict chemotherapy- and immunotherapy-induced heart damage

  A pharmacogenomic and pharmacoepigenetic panel is being tested to see if it can predict which breast cancer patients will develop heart damage from chemotherapy or immunotherapy.

  Recruiting Beneficência Portuguesa de São Paulo · Fortaleza, Ceará and 5 other locations · NCT07663357

• Cardiac Side Effects of Systemic Therapy in Early-Stage Breast Cancer

  This study tests whether heart changes seen on ultrasound and blood biomarkers can detect early heart problems in women receiving standard chemotherapy and anti-HER2 therapy for early breast cancer.

  Recruiting Gazi University · Ankara, Ankara · NCT07588425

• Serial contrast cardiac MRI and biomarker testing to detect anthracycline-related heart damage

  This study tries to see if repeated contrast cardiac MRI plus blood, urine, and stool biomarker checks can find early heart damage in people getting anthracycline chemotherapy.

  Recruiting Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF) · Stuttgart · NCT07528586

• Early detection of heart and blood vessel damage from cancer treatments in children and young adults

  This project tests whether newer heart and vessel imaging and stiffness tests can find treatment-related damage earlier in children, adolescents, and young adult cancer patients.

  Recruiting at 5 sites IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna and 4 other locations · NCT07382141

• Machine-learning prediction of heart damage from anthracycline or HER2 cancer therapies

  We will see if a machine-learning score can predict which adults starting anthracycline or HER2-targeted cancer therapies will develop heart damage within one year.

  Recruiting University Hospital, Caen · Caen · NCT07191730

• Cardiovascular problems after allogeneic stem cell transplant

  This study looks at heart-related problems after allogeneic hematopoietic stem cell transplantation to see how often they occur and what factors might predict them.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07157670

• Protecting the heart during chemotherapy for children with leukemia

  This study tests whether certain heart medications can help protect children with leukemia from heart damage caused by chemotherapy.

  Recruiting at 2 sites Phase 3 Ain Shams University · Cairo and 1 other locations · NCT06853951

• AI-based assessment of heart function using ECG wearable monitors

  This study tests if a new AI tool using a wearable heart monitor can accurately check heart function in people with heart failure compared to traditional heart scans.

  Recruiting at 8 sites Peerbridge Health, Inc · Orange, California and 7 other locations · NCT06699056

• Exercise and fitness program for breast cancer survivors to improve heart health

  This study tests whether a special exercise and yoga program can help breast cancer survivors over 60 improve their heart health and physical fitness after treatment.

  Recruiting University of Alberta · Edmonton, Alberta · NCT06595147

• Monitoring heart health in breast cancer patients receiving trastuzumab

  This study is testing if measuring a specific blood marker can help track heart health in breast cancer patients getting trastuzumab treatment, to see if it can replace traditional heart scans.

  Recruiting Vastra Gotaland Region · Gothenburg · NCT06340516

• Effects of exercise training in lymphoma survivors

  This study is testing whether adding aerobic and resistance exercise to usual care can improve fitness and health for people who have survived lymphoma.

  Recruiting Norwegian School of Sport Sciences · Oslo and 1 other locations · NCT06270667

• Stopping heart failure medications in cancer survivors with heart dysfunction

  This study is testing if cancer survivors with improved heart function can safely stop taking their heart failure medications to see if it reduces their pill burden and side effects.

  Recruiting at 8 sites Phase 4 University Health Network, Toronto · Los Angeles, California and 13 other locations · NCT06183437

• Intensive blood pressure management during breast cancer treatment

  This study is testing if a more aggressive way to manage high blood pressure is safer and works better for people getting chemotherapy for breast cancer.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06023576

• Long-term effects of breast cancer treatment on heart function

  This study looks at how breast cancer treatments affect heart health in women who survived breast cancer to see if any heart problems they had in the past might get worse over time.

  Recruiting University Medical Center Groningen · Groningen · NCT05851053

• Using Nicotinamide Riboside to Prevent Heart Problems in Breast Cancer Patients

  This study is trying to see if a supplement called nicotinamide riboside can help prevent heart problems in women with metastatic breast cancer who are receiving certain chemotherapy treatments.

  Recruiting Phase 2 University Hospital, Akershus · Lørenskog, Akershus · NCT05732051

• Global Cardio Oncology Registry

  This study is collecting health information from cancer patients around the world to see what factors might increase their risk of heart problems caused by cancer treatments.

  Recruiting The Cleveland Clinic · Weston, Florida · NCT05598879

• Using Sacubitril/Valsartan to prevent heart damage in breast cancer treatment

  This study is testing if the medication Sacubitril/Valsartan can help protect the hearts of women undergoing treatment for breast cancer from damage.

  Recruiting at 3 sites Phase 4 Silesian Centre for Heart Diseases · Opole, Opole Voivodeship and 3 other locations · NCT05465031

• Cardiac rehabilitation for young cancer survivors

  This study tests a special exercise program for young cancer survivors to see if it can help improve their heart health and overall fitness.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05023785

• Proton radiotherapy for thymic tumors

  This study is testing whether proton beam radiotherapy can help people with thymic tumors feel better and live longer after surgery or if their tumors can’t be removed.

  Recruiting at 2 sites Swedish Lung Cancer Study Group · Umeå, Norrland and 2 other locations · NCT04822077

• Assessing heart damage in young cancer survivors

  This study is trying to find out if heart damage can be detected early in young cancer survivors who received certain chemotherapy treatments, to help prevent future heart problems.

  Recruiting University of California, San Diego · San Diego, California · NCT04262830

• Preventing heart issues in elderly cancer patients

  This study is testing whether close heart monitoring and teamwork among doctors can help older cancer patients avoid heart problems and live longer compared to standard care.

  Recruiting Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León · Santiago de Compostela, A Coruña and 13 other locations · NCT03711110

• Using carvedilol to prevent heart problems in patients with advanced HER-2-positive breast cancer

  This study is testing if the heart medication carvedilol can help prevent heart problems in patients with advanced HER-2-positive breast cancer who are being treated with trastuzumab.

  Recruiting at 145 sites Phase 3 SWOG Cancer Research Network · Anchorage, Alaska and 589 other locations · NCT03418961

NIH-funded research (newest 40 of 78)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Dual targeting of heart cell receptors to prevent chemotherapy heart damage

  Atrial patients receiving the chemotherapy drug doxorubicin may be protected from heart damage by targeting two heart cell receptors at once.

  NIH research University of Arizona · Tucson, United States · NIH-11536674

• Genetic clues for doxorubicin heart risk using patient-derived heart cells

  A research project tests how human heart cells grown from stem cells react to a common chemotherapy to see which genetic differences may raise the risk of heart damage.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11468369

• Targeting STK3 to protect the heart during breast cancer treatment

  A new approach tests whether blocking STK3 can protect the heart from chemotherapy damage without reducing its cancer-fighting effect in breast cancer patients.

  NIH research Augusta University · Augusta, United States · NIH-11459014

• High-throughput 3D human heart tissue to screen drug safety

  A Johns Hopkins team is creating a high-throughput, 3D human heart tissue model to test drug safety on human heart cells.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11450811

• Precision imaging of heart damage from cancer treatment using metabolic MRI biomarkers

  Researchers will use advanced MRI to find early metabolic signs of heart injury in cancer patients treated with common drugs, so doctors can protect the heart earlier.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11435135

• PET imaging to detect heart damage from chemotherapy

  This research tests a new PET imaging tracer to detect early heart muscle damage in people who have received cancer chemotherapy.

  NIH research Washington University · Saint Louis, United States · NIH-11415784

• Protecting the heart from cancer drugs like ibrutinib

  A team at Stanford is studying how certain cancer drugs can cause heart rhythm problems and is testing ways to prevent those effects.

  NIH research Stanford University · Stanford, United States · NIH-11415075

• Cardiotoxicity from covalent kinase inhibitors explained

  A Stanford team is studying why certain cancer drugs (kinase inhibitors) can harm the heart, so doctors can prevent and manage these effects in patients.

  NIH research Stanford University · Stanford, United States · NIH-11415073

• Carbonic Anhydrase as a Heart-Protective Target During Anthracycline Chemotherapy

  Aims to protect the heart of breast cancer patients who receive anthracycline chemotherapy by studying a specific enzyme, Carbonic Anhydrase XII, to prevent cardiotoxicity.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11405058

• New patient biomarkers for BTK inhibitor–related heart toxicity

  This research looks at why some adults with chronic lymphocytic leukemia develop heart rhythm problems when taking BTK inhibitors and aims to find markers to predict and prevent it.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11402563

• Programmed Cell Death 4 and heart protection during doxorubicin treatment

  A研究 grant looking at how a heart-protective gene called PDCD4 helps prevent heart damage in children treated with doxorubicin chemotherapy.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-11395225

• Understanding how sex hormones and genes affect heart damage from radiation

  This grant tests how estrogen and genetic differences influence who gets heart damage after radiation, using patient-derived heart cells and animal models.

  NIH research Stanford University · Stanford, United States · NIH-11390999

• Understanding how MEK inhibitors may harm the heart in some breast cancer patients

  A cancer drug (MEK inhibitor Trametinib) that helps treat tumors might cause heart problems in some people, and this study will look at why that happens.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11386423

• Understanding why some patients have heart damage from doxorubicin and how to predict it

  This grant looks at why doxorubicin can damage the heart in some patients and how genetic differences, especially related to oxidative stress, might help predict who is at higher risk.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11379116

• A new approach to protect the heart after radiation exposure

  This project aims to develop a post-exposure strategy to reduce heart damage after dangerous radiation, potentially helping people exposed in accidents or attacks.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11378776

• Aging-linked genetic modifiers and therapies for heart damage from cancer drugs

  This grant studies how aging-related genetic factors influence heart damage caused by anthracycline chemotherapy and explores potential therapies.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11377960

• Mitochondrial DNA Instability and ZBP1 in chemotherapy-related heart damage

  This grant tests how a heart-protective pathway involving ZBP1 might prevent heart damage caused by common cancer drugs like doxorubicin.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11376647

• Mitochondrial problems linked to heart damage from ponatinib in cancer patients

  A patient-facing look at how ponatinib, a cancer drug, can affect the heart and how mitochondria and stress responses might explain this side effect.

  NIH research University of Arizona · Tucson, United States · NIH-11374776

• Cardiotoxicity in kids with relapsed AML and what it means for their hearts

  A study tracking how chemotherapy for relapsed pediatric AML affects heart health over time and what that means for long-term wellbeing.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11367516

• PPAR-alpha and sex differences in chemotherapy-related heart injury

  This project looks at why doxorubicin causes different heart side effects in men and women, and tests heart-protective ideas to help patients who need this chemotherapy.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11363534

• Lysosomal membrane leaks and doxorubicin heart damage in cancer treatment

  This grant looks at how a heart cell’s lysosomes react to the chemotherapy drug doxorubicin and how this may cause heart damage in cancer patients.

  NIH research New York Inst of Technology · Old Westbury, United States · NIH-11360249

• Predicting heart problems in breast cancer patients using an AI system

  A multimodal AI system will help doctors predict who may develop heart-related side effects during or after breast cancer treatment and guide safer therapy choices.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11360214

• Cardiac toxicity from osimertinib in cancer patients and ways to prevent it

  This grant studies why the cancer drug osimertinib can harm the heart and tests strategies to stop this damage, with the goal of helping patients stay on life-saving cancer therapy safely.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11337938

• Preventing heart damage from EGFR-targeting cancer drugs

  This project looks for ways to prevent or reverse heart damage caused by EGFR-targeting cancer drugs like osimertinib for people treated for lung and other cancers.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11330172

• Preventing heart damage from chemotherapy in older lymphoma patients

  This study is looking to help older adults with lymphoma by finding ways to prevent heart damage from chemotherapy, figuring out who might be at risk, and understanding what patients and doctors prefer when it comes to treatment options.

  NIH research Beth Israel Deaconess Medical Center · Boston, United States · NIH-11301152

• Identifying druggable targets to protect the heart from cancer therapy side effects

  A Stanford-led study aims to find heart-protective targets to prevent cardiovascular problems caused by cancer drugs in patients.

  NIH research Stanford University · Stanford, United States · NIH-11297105

• Removing mitochondrial iron to protect the heart during doxorubicin treatment

  A treatment approach to protect the hearts of people getting doxorubicin chemotherapy by removing excess iron from heart cell mitochondria.

  NIH research University of Massachusetts Lowell · Lowell, United States · NIH-11252877

• PET scan using F‑AraG to find early heart damage from chemotherapy and immune therapy

  This uses a PET imaging tracer called F‑AraG to spot early heart injury in people getting doxorubicin or immune checkpoint inhibitor cancer treatments.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11243479

• Predicting radiation-related heart damage with patient stem cells

  Using stem cells made from people who had cancer, researchers seek to understand why some patients' hearts are harmed by radiation and to find existing drugs that might protect them.

  NIH research Stanford University · Stanford, United States · NIH-11231257

• Investigating heart damage caused by cancer drugs using advanced human models

  This study is looking at how certain cancer drugs called tyrosine kinase inhibitors might affect your heart, using a new method that combines human heart tissue and advanced technology to help find any heart problems early on, making cancer treatments safer for everyone.

  NIH research University of North Texas · Denton, United States · NIH-11192971

• Protecting the heart from side effects of cancer kinase drugs

  Finding medicines or strategies to prevent irregular heart rhythms in adults treated with certain cancer drugs called kinase inhibitors.

  NIH research Stanford University · Stanford, United States · NIH-11174564

• Why some targeted cancer drugs can affect the heart

  This project will find out whether a heart protein called CSK explains why the cancer drug ibrutinib can cause irregular heartbeats.

  NIH research Stanford University · Stanford, United States · NIH-11174549

• Preventing chemo-related heart damage in African American children

  This project uses patients' own lab-grown heart cells to find genetic risks and ways to stop heart damage from the chemotherapy drug doxorubicin in African American children treated for cancer.

  NIH research Northwestern University · Chicago, United States · NIH-11146712

• Understanding Heart Damage from Doxorubicin Chemotherapy

  This research explores why some patients experience heart damage from doxorubicin chemotherapy while others don't, focusing on individual genetic differences.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11143034

• How MEK cancer drugs can damage heart mitochondria

  This project looks at whether MEK-targeting cancer drugs like trametinib harm the mitochondria in heart muscle and cause heart problems in people treated for cancers such as melanoma or triple-negative breast cancer.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11142507

• Investigating heart damage caused by cancer treatments using lab-grown heart cells.

  This study is looking at how some cancer treatments might hurt the heart, and it's for anyone interested in making cancer therapies safer by using lab-grown heart cells to see how these drugs affect heart function.

  NIH research Vala Sciences, INC. · San Diego, United States · NIH-11142334

• Investigating heart damage caused by cancer treatments using lab-grown heart cells.

  This study is looking at how some cancer treatments might harm the heart, using special lab-grown heart cells to see how chemotherapy affects heart function, which could help doctors better understand and predict heart problems in cancer survivors.

  NIH research Vala Sciences, INC. · San Diego, United States · NIH-11142333

• Investigating heart damage caused by cancer treatments using lab-grown heart cells.

  This study is looking at how some cancer treatments might harm the heart, using special lab-grown heart cells to see how chemotherapy affects heart function, which could help make cancer treatments safer for patients like you.

  NIH research Vala Sciences, INC. · San Diego, United States · NIH-11142332

• Sex and estrogen effects on radiation-related heart damage

  This project looks at how estrogen and genetic differences change how people's hearts respond to radiation using lab-grown human heart tissues and animal models.

  NIH research Stanford University · Stanford, United States · NIH-11141873

• Targeting specific receptors to reduce heart damage from cancer treatment

  This study is looking at how certain proteins in the body can help protect your heart from damage caused by the chemotherapy drug doxorubicin, with the hope of finding better ways to keep your heart healthy while you’re being treated for cancer.

  NIH research University of Louisville · Louisville, United States · NIH-11138735

Related topics

Quick answers

How many Cardiotoxicity clinical trials are recruiting right now?

24, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (7 trials), Sweden (4 trials), Canada (3 trials), France (2 trials), Poland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 3: 2, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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