Using cardiac imaging to identify early signs of heart disease in families at risk
Official title: Precision Medicine for Dilated Cardiomyopathy-Cardiac Magnetic Resonance to Identify Early Family Phenotypes
Funded at Ohio State University · NIH-10895268 · Data updated 2026-11-12
This study is looking at how special heart scans can spot early signs of dilated cardiomyopathy in family members of people who have the condition, helping to catch any changes in the heart before symptoms appear.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $761,272 |
| NIH project number | 5R01HL148581-04 |
| Project ID | NIH-10895268 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are first-degree relatives of individuals diagnosed with dilated cardiomyopathy who may carry genetic variants associated with the disease.
✕Less likely to help
Patients without a family history of dilated cardiomyopathy or those not carrying relevant genetic variants may not benefit from this research.
What this research studies
This research investigates how cardiac magnetic resonance (CMR) imaging can detect early signs of dilated cardiomyopathy (DCM) in individuals who have a genetic predisposition due to family history. It focuses on first-degree relatives of DCM patients, aiming to identify myocardial tissue changes before the disease manifests. By analyzing specific imaging characteristics, the study seeks to correlate these findings with genetic variants associated with DCM, potentially allowing for earlier intervention and better management of the condition.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and treatment of dilated cardiomyopathy, improving outcomes for at-risk individuals.
How similar studies have gone: Previous research has shown that cardiac imaging techniques can successfully identify early myocardial changes in patients at risk for heart diseases, supporting the potential effectiveness of this approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Hershberger, Ray E. — Ohio State University
- Study coordinator: Hershberger, Ray E.
Related research
Other NIH-funded projects on the same topics.
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Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data
A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.
-
Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it
This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.
-
Unlocking how rare genetic changes cause dilated cardiomyopathy
A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.
-
Role of Lmod2 in heart muscle and dilated cardiomyopathy
This NIH grant explores how a heart-specific protein (Lmod2) helps heart cells contract properly and how its problems can cause dilated cardiomyopathy in infants and children.
-
Targeting DNA Damage Pathways in LMNA-Related Heart Disease
A study to understand how damaged DNA and inflammatory signals contribute to dilated cardiomyopathy caused by LMNA mutations and explore therapies that can protect the heart.
-
Using miRNA to find new treatment paths for dilated cardiomyopathy
Researchers are studying heart-muscle disease (dilated cardiomyopathy) to discover miRNA-based clues that could lead to targeted therapies for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.