Understanding heart disease caused by faulty protein signaling
Dysregulated mechanosignaling in dilated cardiomyopathy caused by defective Filamin C
This study is looking at how problems with a protein called Filamin C affect heart function in people with dilated cardiomyopathy (DCM), with the hope of finding better ways to diagnose and treat this heart condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10894897 on NIH RePORTER |
What this research studies
This research investigates dilated cardiomyopathy (DCM), a serious heart condition linked to mutations in proteins that help heart cells communicate and respond to mechanical forces. The study focuses on how defects in a specific protein, Filamin C, disrupt the signaling pathways that are crucial for heart muscle function. By using advanced techniques like atomic force microscopy, researchers aim to uncover the mechanisms behind these defects and their impact on heart cell behavior. This could lead to new insights into how to better diagnose and treat DCM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those with a family history of the condition.
Not a fit: Patients with heart conditions unrelated to dilated cardiomyopathy or those without genetic mutations affecting heart proteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for patients with dilated cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in understanding mechanosignaling in heart diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Powers, Joseph D. — University of Washington
- Study coordinator: Powers, Joseph D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.