Understanding how microRNAs affect heart function in dilated cardiomyopathy
MicroRNA Control of Dilated Cardiomyopathy
['FUNDING_R01'] · STANFORD UNIVERSITY · NIH-11223478
This study is looking at tiny molecules called microRNAs to see how they can help improve heart function in people with dilated cardiomyopathy, a condition that can lead to heart failure, by finding new ways to treat the genetic issues behind it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11223478 on ClinicalTrials.gov |
What this research studies
This research investigates the role of microRNAs in dilated cardiomyopathy (DCM), a condition that can lead to heart failure. By using advanced techniques, the researchers aim to identify specific genes that, when targeted, can improve heart muscle function in patients with genetic mutations linked to DCM. The study involves screening synthetic microRNAs to find those that can restore the contractility of heart cells derived from patients. Ultimately, the goal is to uncover new therapeutic strategies that can directly address the underlying causes of DCM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those with genetic mutations affecting cardiac muscle proteins.
Not a fit: Patients without dilated cardiomyopathy or those whose heart failure is not linked to genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and quality of life for patients with dilated cardiomyopathy.
How similar studies have performed: Previous research has shown promise in using microRNAs to target genetic mutations in heart diseases, indicating a potential for success in this novel approach.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MERCOLA, MARK — STANFORD UNIVERSITY
- Study coordinator: MERCOLA, MARK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Candidate Disease Gene