Understanding the causes of sudden cardiac death in patients with dilated cardiomyopathy.
Elucidating the Origin of Sudden Cardiac Death in Dilated Cardiomyopathy: from Phenotype Predictors to Therapeutic Targets
This study is looking at how certain genetic factors and heart changes can help doctors find out which patients with dilated cardiomyopathy are at risk for serious heart problems, so they can create better treatments and prevention plans for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11047759 on NIH RePORTER |
What this research studies
This research investigates the underlying mechanisms and clinical predictors of life-threatening arrhythmias in patients suffering from dilated cardiomyopathy (DCM). By examining genetic factors and cardiac fibrosis, the study aims to identify patients at high risk for sudden cardiac death (SCD) through advanced imaging and genetic testing. The research employs a multidisciplinary approach, combining clinical assessments with innovative techniques like NextGen sequencing to enhance patient outcomes. Ultimately, the goal is to develop targeted therapies and prevention strategies for those affected by DCM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those exhibiting symptoms of arrhythmias or cardiac dysfunction.
Not a fit: Patients with non-cardiac related conditions or those without a diagnosis of dilated cardiomyopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and treatment of patients at risk for sudden cardiac death, potentially saving lives.
How similar studies have performed: Previous research has shown promise in identifying genetic and phenotypic predictors of arrhythmias in similar patient populations, suggesting that this approach could yield significant insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Mestroni, Luisa — University of Colorado Denver
- Study coordinator: Mestroni, Luisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.