Understanding the causes of sudden cardiac death in patients with dilated cardiomyopathy.
Official title: Elucidating the Origin of Sudden Cardiac Death in Dilated Cardiomyopathy: from Phenotype Predictors to Therapeutic Targets
Funded at University of Colorado Denver · NIH-11047759 · Data updated 2026-11-12
This study is looking at how certain genetic factors and heart changes can help doctors find out which patients with dilated cardiomyopathy are at risk for serious heart problems, so they can create better treatments and prevention plans for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | April 5, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $611,225 |
| NIH project number | 5R01HL164634-03 |
| Project ID | NIH-11047759 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with dilated cardiomyopathy, particularly those exhibiting symptoms of arrhythmias or cardiac dysfunction.
✕Less likely to help
Patients with non-cardiac related conditions or those without a diagnosis of dilated cardiomyopathy may not benefit from this research.
What this research studies
This research investigates the underlying mechanisms and clinical predictors of life-threatening arrhythmias in patients suffering from dilated cardiomyopathy (DCM). By examining genetic factors and cardiac fibrosis, the study aims to identify patients at high risk for sudden cardiac death (SCD) through advanced imaging and genetic testing. The research employs a multidisciplinary approach, combining clinical assessments with innovative techniques like NextGen sequencing to enhance patient outcomes. Ultimately, the goal is to develop targeted therapies and prevention strategies for those affected by DCM.
Why it matters
Potential benefit: If successful, this research could lead to improved identification and treatment of patients at risk for sudden cardiac death, potentially saving lives.
How similar studies have gone: Previous research has shown promise in identifying genetic and phenotypic predictors of arrhythmias in similar patient populations, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Mestroni, Luisa — University of Colorado Denver
- Study coordinator: Mestroni, Luisa
Related research
Other NIH-funded projects on the same topics.
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Finding why sudden cardiac death happens in dilated cardiomyopathy and how to stop it
Looks at whether genetics and heart scarring can predict and help prevent deadly heart rhythms in people with dilated cardiomyopathy.
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Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data
A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.
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Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it
This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.
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Unlocking how rare genetic changes cause dilated cardiomyopathy
A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.
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Role of Lmod2 in heart muscle and dilated cardiomyopathy
This NIH grant explores how a heart-specific protein (Lmod2) helps heart cells contract properly and how its problems can cause dilated cardiomyopathy in infants and children.
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Targeting DNA Damage Pathways in LMNA-Related Heart Disease
A study to understand how damaged DNA and inflammatory signals contribute to dilated cardiomyopathy caused by LMNA mutations and explore therapies that can protect the heart.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.