Assessing genetic risk factors for dilated cardiomyopathy
Official title: Population Assessments of Aggregate Genetic Risk for Dilated Cardiomyopathy
Funded at Massachusetts General Hospital · NIH-10910905 · Data updated 2026-11-12
This study is looking at how our genes might affect the risk of developing dilated cardiomyopathy, a serious heart condition, so that patients can get better screening and personalized treatments based on their genetic makeup.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $169,560 |
| NIH project number | 5K08HL153937-04 |
| Project ID | NIH-10910905 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of dilated cardiomyopathy or those exhibiting early signs of heart disease.
✕Less likely to help
Patients with no genetic predisposition to dilated cardiomyopathy or those with unrelated heart conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to dilated cardiomyopathy, a serious heart condition. By analyzing genetic data and clinical information, the study aims to identify individuals at higher risk for developing this condition. Patients may benefit from advanced genetic screening and personalized treatment options based on their genetic profiles. The research involves collaboration between experts in cardiology, genetics, and epidemiology to ensure a comprehensive approach.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted therapies for patients with dilated cardiomyopathy.
How similar studies have gone: Previous research has shown promising results in using genetic assessments to predict cardiovascular diseases, indicating a strong potential for success in this area.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Aragam, Krishna G — Massachusetts General Hospital
- Study coordinator: Aragam, Krishna G
Related research
Other NIH-funded projects on the same topics.
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Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data
A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.
-
Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it
This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.
-
Unlocking how rare genetic changes cause dilated cardiomyopathy
A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.
-
Role of Lmod2 in heart muscle and dilated cardiomyopathy
This NIH grant explores how a heart-specific protein (Lmod2) helps heart cells contract properly and how its problems can cause dilated cardiomyopathy in infants and children.
-
Targeting DNA Damage Pathways in LMNA-Related Heart Disease
A study to understand how damaged DNA and inflammatory signals contribute to dilated cardiomyopathy caused by LMNA mutations and explore therapies that can protect the heart.
-
Using miRNA to find new treatment paths for dilated cardiomyopathy
Researchers are studying heart-muscle disease (dilated cardiomyopathy) to discover miRNA-based clues that could lead to targeted therapies for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.