How mutations in heart muscle proteins affect heart function
Impact of dilated cardiomyopathy mutations on cardiac myosin structure and function
['FUNDING_R01'] · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · NIH-10983294
This study looks at how certain genetic changes linked to dilated cardiomyopathy (DCM) affect a key protein in your heart that helps it pump blood, with the goal of finding out more about heart failure and helping develop better treatments for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIV HERSHEY MED CTR (nih funded) |
| Locations | 1 site (HERSHEY, UNITED STATES) |
| Trial ID | NIH-10983294 on ClinicalTrials.gov |
What this research studies
This research investigates how specific genetic mutations associated with dilated cardiomyopathy (DCM) impact the structure and function of cardiac myosin, a crucial protein for heart muscle contraction. By examining these mutations, the study aims to understand the molecular mechanisms that lead to heart failure. Patients may benefit from insights gained into how these mutations affect heart performance, potentially guiding future therapies. The research employs advanced biochemical and biophysical techniques to analyze the interactions between myosin and actin filaments in heart muscle cells.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with dilated cardiomyopathy, particularly those with known genetic mutations.
Not a fit: Patients without dilated cardiomyopathy or those with heart failure due to non-genetic causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for patients with dilated cardiomyopathy.
How similar studies have performed: Previous research has shown promising results in understanding the molecular basis of heart diseases through similar approaches, indicating potential for success in this study.
Where this research is happening
HERSHEY, UNITED STATES
- PENNSYLVANIA STATE UNIV HERSHEY MED CTR — HERSHEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YENGO, CHRISTOPHER M — PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- Study coordinator: YENGO, CHRISTOPHER M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.