Understanding Lmod2's role in heart muscle and dilated cardiomyopathy
Official title: Deciphering the role of Lmod2 in cardiac muscle and in dilated cardiomyopathy
Funded at Icahn School of Medicine at Mount Sinai · NIH-11227167 · Data updated 2026-11-12
This project looks at how problems with the Lmod2 protein harm heart muscle in people with dilated cardiomyopathy and explores ways to restore its function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2015 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $834,603 |
| NIH project number | 2R01HL123078-10 |
| Project ID | NIH-11227167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal participants would be people diagnosed with dilated cardiomyopathy, especially those with early-onset disease or known LMOD2 mutations.
✕Less likely to help
Patients whose heart failure is caused by ischemic heart disease, structural problems unrelated to LMOD2, or other non-LMOD2 genetic causes may be unlikely to benefit from LMOD2-directed therapies.
What this research studies
You can think of Lmod2 as a protein that helps build the thin filaments muscle cells need to contract, and researchers are studying how changes in Lmod2 lead to weakened hearts. They use lab models, genetic analyses, and patient-derived samples to see how mutations cause loss of Lmod2 protein and change muscle activation. The team is testing methods such as steric-blocking oligonucleotides to restore LMOD2 expression and is examining altered signalling pathways that affect contraction. Findings from these steps aim to link molecular problems to heart function and point toward targeted treatments.
Why it matters
Potential benefit: If successful, this work could lead to targeted therapies that restore LMOD2 protein and improve heart function in people with dilated cardiomyopathy.
How similar studies have gone: Prior lab studies show that restoring LMOD2 expression can correct defects in models, but clinical benefit in patients has not yet been demonstrated.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Gregorio, Carol C — Icahn School of Medicine at Mount Sinai
- Study coordinator: Gregorio, Carol C
Related research
Other NIH-funded projects on the same topics.
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Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data
A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.
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Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it
This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.
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Unlocking how rare genetic changes cause dilated cardiomyopathy
A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.
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Role of Lmod2 in heart muscle and dilated cardiomyopathy
This NIH grant explores how a heart-specific protein (Lmod2) helps heart cells contract properly and how its problems can cause dilated cardiomyopathy in infants and children.
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Targeting DNA Damage Pathways in LMNA-Related Heart Disease
A study to understand how damaged DNA and inflammatory signals contribute to dilated cardiomyopathy caused by LMNA mutations and explore therapies that can protect the heart.
-
Using miRNA to find new treatment paths for dilated cardiomyopathy
Researchers are studying heart-muscle disease (dilated cardiomyopathy) to discover miRNA-based clues that could lead to targeted therapies for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.