Understanding how protein stress affects heart function in genetic heart disease
Investigating the role of the Unfolded Protein Response in Genetic Dilated Cardiomyopathy
This study is looking at how a specific stress response in heart cells might help people with Genetic Dilated Cardiomyopathy (DCM) feel better, by using heart cells made from patients' own stem cells to see how they react to problems caused by misfolded proteins.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10998462 on NIH RePORTER |
What this research studies
This research investigates the role of the Unfolded Protein Response (UPR) in patients with Genetic Dilated Cardiomyopathy (DCM), a condition that leads to heart failure. By using induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with DCM mutations, the study aims to explore how these cells respond to stress caused by misfolded proteins. The researchers will examine the activation of the UPR and its potential to improve heart cell function, providing insights into new therapeutic strategies for DCM.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Genetic Dilated Cardiomyopathy, particularly those with known genetic mutations associated with the condition.
Not a fit: Patients without a diagnosis of Genetic Dilated Cardiomyopathy or those with non-genetic forms of heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce the risk of heart failure in patients with genetic DCM.
How similar studies have performed: Previous research has shown promising results in using similar approaches to study heart diseases, indicating potential for success in this area.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Baum, Rachel — Stanford University
- Study coordinator: Baum, Rachel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.