Understanding how microRNAs affect heart function in dilated cardiomyopathy
MicroRNA Control of Dilated Cardiomyopathy
This study is looking at tiny molecules called microRNAs to see how they can help improve heart function in people with dilated cardiomyopathy, a condition that can lead to heart failure, by finding new ways to target specific genes that cause this issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11000356 on NIH RePORTER |
What this research studies
This research investigates the role of microRNAs in dilated cardiomyopathy (DCM), a condition that leads to heart failure. By using advanced techniques, the team aims to identify specific genes that, when targeted, can improve heart muscle function in patients with DCM-causing mutations. The study involves screening synthetic microRNAs to discover potential therapeutic interventions that could restore normal heart function. The findings could lead to new treatments that directly address the underlying genetic causes of DCM.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with dilated cardiomyopathy, particularly those with known genetic mutations affecting cardiac muscle proteins.
Not a fit: Patients without dilated cardiomyopathy or those whose heart failure is not linked to genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve heart function and quality of life for patients with dilated cardiomyopathy.
How similar studies have performed: Previous research has shown promise in using microRNA approaches for cardiac conditions, indicating potential for success in this novel application.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Mercola, Mark — Stanford University
- Study coordinator: Mercola, Mark
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.