Understanding heart mechanics in patients with dilated cardiomyopathy
Official title: Precision Medicine for Dilated Cardiomyopathy—Novel Assessment of Cardiac Mechanics via Speckle Tracking Echocardiography to Identify Early Phenotypes
Funded at Ohio State University · NIH-10436899 · Data updated 2026-11-12
This study is looking at how we can better understand heart function in people with dilated cardiomyopathy (DCM) by using special ultrasound techniques, especially for those who might be at risk due to their genes, so we can catch any early signs of heart issues and tailor treatments just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2022 |
| Award (this year) | $392,992 |
| NIH project number | 5R01HL149423-04 |
| Project ID | NIH-10436899 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with dilated cardiomyopathy and their family members who may also be at risk due to genetic factors.
✕Less likely to help
Patients with dilated cardiomyopathy that is clearly diagnosed and managed without genetic considerations may not benefit from this research.
What this research studies
This research investigates how specific heart mechanics can be assessed in patients with dilated cardiomyopathy (DCM) using advanced echocardiography techniques. By analyzing cardiac function in individuals who may be genetically predisposed to DCM, the study aims to identify early signs of the disease before significant heart damage occurs. Participants will undergo echocardiographic evaluations to gather detailed data on their heart's performance, which will be correlated with genetic testing results. This approach seeks to enhance early diagnosis and personalized treatment strategies for those at risk of developing heart failure.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of dilated cardiomyopathy, potentially improving patient outcomes.
How similar studies have gone: Other research has shown promise in using advanced echocardiographic techniques to assess heart conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Hershberger, Ray E. — Ohio State University
- Study coordinator: Hershberger, Ray E.
Related research
Other NIH-funded projects on the same topics.
-
Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data
A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.
-
Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it
This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.
-
Unlocking how rare genetic changes cause dilated cardiomyopathy
A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.
-
Role of Lmod2 in heart muscle and dilated cardiomyopathy
This NIH grant explores how a heart-specific protein (Lmod2) helps heart cells contract properly and how its problems can cause dilated cardiomyopathy in infants and children.
-
Targeting DNA Damage Pathways in LMNA-Related Heart Disease
A study to understand how damaged DNA and inflammatory signals contribute to dilated cardiomyopathy caused by LMNA mutations and explore therapies that can protect the heart.
-
Using miRNA to find new treatment paths for dilated cardiomyopathy
Researchers are studying heart-muscle disease (dilated cardiomyopathy) to discover miRNA-based clues that could lead to targeted therapies for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.