Understanding heart muscle weakness from a protein defect
Dysregulated mechanosignaling in dilated cardiomyopathy caused by defective Filamin C
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-11163432
This work explores how a specific protein defect in heart muscle cells contributes to a common form of inherited heart weakness called dilated cardiomyopathy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11163432 on ClinicalTrials.gov |
What this research studies
Our hearts rely on a network of proteins to sense and respond to forces, which is crucial for healthy pumping. In dilated cardiomyopathy (DCM), these protein networks, especially one called the costamere, might not work correctly. This project looks at how defects in a protein called Filamin C, found in the costamere, prevent heart muscle cells from properly transmitting and responding to mechanical signals. We believe these defects lead to the heart's inability to contract well and cause harmful changes to heart cells, which are hallmarks of DCM.
Who could benefit from this research
Good fit: This foundational work is relevant for patients with familial dilated cardiomyopathy, particularly those with known or suspected defects in proteins like Filamin C.
Not a fit: Patients with heart conditions unrelated to genetic defects in mechanosignaling proteins may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the causes of dilated cardiomyopathy and potentially new ways to treat or prevent this condition.
How similar studies have performed: While Filamin C has recently been linked to various human cardiomyopathies, this specific approach using a new mouse model to understand mechanosignaling dysfunction is a novel extension of existing knowledge.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POWERS, JOSEPH D. — UNIVERSITY OF WASHINGTON
- Study coordinator: POWERS, JOSEPH D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders