Bromocriptine treatment for women with dilated cardiomyopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of bromocriptine mesylate in women aged 18 to 50 with dilated cardiomyopathy, a condition characterized by the enlargement and weakening of the heart's ventricles. The study aims to assess the drug's efficacy in improving left ventricular function and overall heart health compared to standard guideline-directed medical therapy. By focusing on the hormonal influences of prolactin in this patient population, the trial seeks to provide insights into a potentially novel treatment approach for a condition that significantly impacts young women. Participants will be monitored for improvements in heart function and any adverse reactions to the treatment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women age 18 years to 50 years and
* ischemic or de novo dilated cardiomyopathy

Exclusion Criteria:

* Patients with severe comorbidities which may worsen their illness
* with hypertensive heart diseases
* Rheumatic valvular heart diseases
* Restrictive cardiomyopathy, constrictive cardiomyopathy, hypertrophic cardiomyopathy
* Congenital heart diseases
* Acute coronary syndrome
* Overt kidney failure (serum Creatinine ≥ 1.4mg/dl),
* Women who had history of peripartal cardiomyopathy, are pregnant or planning pregnancy during the study period or lactating
* Previous adverse reaction to the bromocriptine
* Patients not willing to participate in the study

Where it's running

• Jimma Medical Center
  Jimma, Oromiya, Ethiopia Recruiting

Study contacts

• Principal investigator: Kedir N Tukeni, MD — Jimma University
• Study coordinator: Kedir N Tukeni, MD
• Email: Kedir.negesso@ju.edu.et
• Phone: +251913521475

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• AZD4063 for PLN R14del dilated cardiomyopathy.

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  Recruiting at 4 sites Phase 1 AstraZeneca · Amsterdam and 3 other locations · NCT07241104

• Identifying patients with cardiomyopathy for potential heart transplantation

  This study is trying to find new ways to identify and understand cardiomyopathy in patients to better predict if they might need a heart transplant in the future.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Emilia-Romagna/Bologna and 2 other locations · NCT06813443

• Predicting Ventricular Tachycardia Events in Patients with Non-Ischemic Cardiomyopathy

  This study is trying to see if certain heart imaging tests can help predict the risk of dangerous heart rhythms and sudden cardiac death in people with non-ischemic cardiomyopathy.

  Recruiting at 4 sites Centro Medico Teknon · Milan, Italy and 3 other locations · NCT06730464

• AI-based assessment of heart function using ECG wearable monitors

  This study tests if a new AI tool using a wearable heart monitor can accurately check heart function in people with heart failure compared to traditional heart scans.

  Recruiting at 8 sites Peerbridge Health, Inc · Orange, California and 7 other locations · NCT06699056

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.