Understanding Cell Communication in Inherited Dilated Cardiomyopathy
Official title: Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy
Funded at Stanford University · NIH-11110408 · Data updated 2026-11-12
This research explores how heart cells communicate with each other in an inherited heart condition called dilated cardiomyopathy, using special human cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 1, 2018 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $676,392 |
| NIH project number | 5R01HL141371-08 |
| Project ID | NIH-11110408 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is relevant to patients living with LMNA-related dilated cardiomyopathy and other inherited heart conditions.
✕Less likely to help
Patients with heart conditions not related to LMNA or other inherited causes may not directly benefit from this specific research.
What this research studies
We are looking into LMNA-related dilated cardiomyopathy, a common inherited heart disease where the heart muscle becomes weak and enlarged. While we know this condition affects heart muscle cells, it also impacts other cells in the heart, like those involved in scarring and blood vessel health. Our goal is to uncover the exact ways these different heart cells talk to each other, which is currently not well understood. We use human stem cells, advanced gene editing, and cutting-edge 'omics' technologies to identify and explore these communication pathways, hoping to find new ways to understand how the disease develops.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of dilated cardiomyopathy and potentially new treatments that target how heart cells communicate.
How similar studies have gone: The precise mechanisms of intercellular communication in LMNA-related dilated cardiomyopathy are not yet clear, making this a novel and important area of investigation.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Wu, Joseph C. — Stanford University
- Study coordinator: Wu, Joseph C.
Related research
Other NIH-funded projects on the same topics.
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Discovery of rare genetic variants linked to dilated cardiomyopathy using big biobank data
A large-scale genetic study will look for rare gene variants that affect dilated cardiomyopathy to improve how we diagnose and manage the condition.
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Understanding how muscle ribosome mutations cause severe neonatal dilated cardiomyopathy and ways to treat it
This grant focuses on a rare genetic heart condition in newborns caused by mutations in a muscle-specific ribosomal protein, with hopes to find new ways to diagnose and treat it.
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Unlocking how rare genetic changes cause dilated cardiomyopathy
A large study will look at genetic data from many people to understand which rare variants affect dilated cardiomyopathy and how this changes risk and treatment.
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Role of Lmod2 in heart muscle and dilated cardiomyopathy
This NIH grant explores how a heart-specific protein (Lmod2) helps heart cells contract properly and how its problems can cause dilated cardiomyopathy in infants and children.
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Targeting DNA Damage Pathways in LMNA-Related Heart Disease
A study to understand how damaged DNA and inflammatory signals contribute to dilated cardiomyopathy caused by LMNA mutations and explore therapies that can protect the heart.
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Using miRNA to find new treatment paths for dilated cardiomyopathy
Researchers are studying heart-muscle disease (dilated cardiomyopathy) to discover miRNA-based clues that could lead to targeted therapies for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.