Understanding Cell Communication in Inherited Dilated Cardiomyopathy
Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy
This research explores how heart cells communicate with each other in an inherited heart condition called dilated cardiomyopathy, using special human cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11110408 on NIH RePORTER |
What this research studies
We are looking into LMNA-related dilated cardiomyopathy, a common inherited heart disease where the heart muscle becomes weak and enlarged. While we know this condition affects heart muscle cells, it also impacts other cells in the heart, like those involved in scarring and blood vessel health. Our goal is to uncover the exact ways these different heart cells talk to each other, which is currently not well understood. We use human stem cells, advanced gene editing, and cutting-edge 'omics' technologies to identify and explore these communication pathways, hoping to find new ways to understand how the disease develops.
Who could benefit from this research
Good fit: This foundational research is relevant to patients living with LMNA-related dilated cardiomyopathy and other inherited heart conditions.
Not a fit: Patients with heart conditions not related to LMNA or other inherited causes may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of dilated cardiomyopathy and potentially new treatments that target how heart cells communicate.
How similar studies have performed: The precise mechanisms of intercellular communication in LMNA-related dilated cardiomyopathy are not yet clear, making this a novel and important area of investigation.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Wu, Joseph C. — Stanford University
- Study coordinator: Wu, Joseph C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.