Condition

Macular Degeneration clinical trials and research

• 18Clinical trials
• 73NIH research projects
• 32Countries

Newest Macular Degeneration clinical trials

All recruiting trials (18)

• Noninvasive imaging biomarkers to see if ophthalmic artery narrowing relates to geographic atrophy in age-related macular degeneration

  This study tests whether narrowed ophthalmic artery vessels are linked to the development or worsening of geographic atrophy in people with dry age-related macular degeneration.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07798323

• Multimodal-feedback vision rehabilitation for people with central vision loss

  This trial will test whether five weekly sessions of binocular multimodal feedback training can improve eye movement control in people with bilateral central vision loss from macular degeneration.

  Recruiting New England College of Optometry · Boston, Massachusetts · NCT07577219

• Tiespectus (MK-8748) versus aflibercept to treat neovascular (wet) age-related macular degeneration

  The study will see if tiespectus (MK-8748) works as well as aflibercept for people with newly diagnosed neovascular (wet) age-related macular degeneration.

  Recruiting at 71 sites Phase 2/3 EyeBiotech Ltd. · Gilbert, Arizona and 70 other locations · NCT07496567

• Comparing tiespectus (MK-8748) with aflibercept for wet age-related macular degeneration

  This study will test whether tiespectus (MK-8748) works as well as aflibercept for people with newly diagnosed neovascular (wet) age-related macular degeneration.

  Recruiting at 132 sites Phase 2/3 EyeBiotech Ltd. · Scottsdale, Arizona and 131 other locations · NCT07440225

• See If Faricimab Helps Neovascular Age-related Macular Degeneration

  This study tests whether Faricimab injections every month for 4 months can help adults aged 50 and older with active neovascular AMD in at least one eye.

  Recruiting at 3 sites Phase 4 Asan Medical Center · Seongnam and 4 other locations · NCT07367282

• Natural history of inherited retinal diseases

  This project will test whether color vision problems relate to retinal structure and visual function in people with inherited retinal dystrophies and in people without retinal disease.

  Recruiting Augelux Therapeutics · Wuhan · NCT07085533

• Assessing a vision test for patients with macular degeneration and Stargardt disease

  This study is testing a new vision test to see how well it works for people with macular degeneration and Stargardt disease compared to standard vision tests.

  Recruiting Nanoscope Therapeutics Inc. · Dallas, Texas · NCT06805474

• Long-term safety assessment of JNJ-81201887 for eye condition related to aging

  This study is testing the long-term safety of a new eye treatment for age-related vision loss in people who have already tried it before.

  Recruiting at 85 sites Phase 2/3 Janssen Research & Development, LLC · Tucson, Arizona and 103 other locations · NCT06635148

• Evaluating a stem cell treatment for geographic atrophy from dry age-related macular degeneration.

  This study is testing a new stem cell treatment for people with geographic atrophy from dry age-related macular degeneration to see if it can help improve their vision.

  Recruiting at 3 sites Phase 1/2 Eyestem Research Pvt. Ltd. · Jālna, Maharashtra and 2 other locations · NCT06394232

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Exploring new imaging techniques for eye diseases

  This study is testing a new eye imaging technique to better understand diseases like diabetic retinopathy and macular degeneration in order to improve treatment for patients.

  Recruiting Johannes Kepler University of Linz · Linz, Upper Austria · NCT06074731

• Understanding visual learning and plasticity in macular degeneration

  This study is testing if training can help people with macular degeneration improve their everyday vision by understanding how their brains adapt to changes in sight.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05454124

• Transplanting stem cells to treat macular degeneration

  This study is testing if using a patient's own stem cells to create new eye cells can help treat age-related macular degeneration in people aged 50 to 75.

  Recruiting Phase 1 Beijing Tongren Hospital · Beijing, Beijing Municipality · NCT05445063

• Using stem cells from umbilical cords to treat non-arteritic ischemic optic neuropathy

  This study is testing if using stem cells from umbilical cords can help people with non-arteritic ischemic optic neuropathy improve their vision and overall eye health.

  Recruiting at 2 sites Phase 1 The Foundation for Orthopaedics and Regenerative Medicine · Naples, Florida and 1 other locations · NCT05147701

• Improving vision in adults with macular degeneration using brain stimulation

  This study is testing whether a new brain stimulation technique can help adults with macular degeneration improve their reading skills and vision.

  Recruiting at 2 sites University of Waterloo · Waterloo, Ontario and 1 other locations · NCT04762368

• MB-102 versus fluorescein sodium for retinal angiography imaging

  This trial will test whether the new dye MB-102 produces safe, high-quality retinal angiography images in adults with healthy eyes or retinal vascular disease compared with standard fluorescein sodium.

  Recruiting Early Phase 1 MediBeacon · Ann Arbor, Michigan · NCT04008121

• Using stem cells to treat retinal and optic nerve damage

  This study is testing if using stem cells from your own bone marrow can help improve vision in people with serious eye damage from conditions like age-related macular degeneration and optic nerve problems.

  Recruiting at 4 sites MD Stem Cells · Westport, Connecticut and 3 other locations · NCT03011541

• Analyzing eye fluid biomarkers in patients with retinal diseases

  This study is trying to see if certain eye fluids can help us understand how serious retinal diseases like diabetic retinopathy and age-related macular degeneration are in patients.

  Recruiting Kyungpook National University Hospital · Daegu, Kyungsangpookdo · NCT02026843

NIH-funded research (newest 40 of 73)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• A Small Molecule PROTAC for Macular Degeneration

  A patient-friendly look at a small molecule therapy designed to target a key inflammation driver in age-related macular degeneration to help protect vision.

  NIH research University of Rochester · Rochester, United States · NIH-11564143

• AI-powered tool to predict 2-year risk of late AMD

  A new AI software helps people at risk of age-related macular degeneration understand their 2-year risk and what steps could protect their vision.

  NIH research Ihealthscreen, INC. · Richmond Hill, UNITED STATES · NIH-11552709

• Active cycling program to support vision and daily living in Veterans with AMD

  A 6-month online group spin cycling program is tested to help Veterans with age-related macular degeneration maintain vision and improve daily functioning.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11456784

• Transplanting stem-cell–derived retinal cells to treat dry AMD

  A medical team is testing a stem cell therapy to replace damaged retinal cells in adults with dry age-related macular degeneration.

  NIH research Regenerative Research Foundation · Albany, UNITED STATES · NIH-11439991

• RPESC-derived RPE Transplant for Dry AMD in adults

  A new cell-based therapy derived from RPESCs is being tested to help adults with dry age-related macular degeneration regain vision.

  NIH research Regenerative Research Foundation · Albany, UNITED STATES · NIH-11436542

• New high-resolution OCT biomarkers to map early AMD changes

  A new imaging approach using advanced OCT methods will help doctors see early changes in age-related macular degeneration to guide treatment and improve quality of life for older adults.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11431137

• Targeting inflammation in age-related macular degeneration

  Aims to understand how inflammation drives age-related macular degeneration in people and explore new targets to slow or stop vision loss.

  NIH research Yale University · New Haven, United States · NIH-11418964

• Early atrophic AMD: understanding how the disease progresses to protect vision

  This NIH grant studies how age-related macular degeneration advances in its early atrophic stage to help prevent vision loss.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11418467

• Inhibiting new blood vessel growth and scarring under the retina in AMD

  This grant tests drug-based strategies to prevent abnormal blood vessel growth and scarring under the retina in adults with age-related macular degeneration.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11418408

• Non-exudative Type 1 MNV and AMD: protect vision with smarter imaging

  This project studies how a specific, non-exudative form of eye blood vessels in AMD might help preserve vision, using advanced eye imaging and patient-friendly tests.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11418359

• PRMT5 inhibitors for tough-to-treat age-related eye disease

  A new PRMT5 inhibitor is being explored as a treatment for people with neovascular age-related macular degeneration who don’t fully respond to current anti-VEGF therapies.

  NIH research Eqon Pharmaceuticals, LLC · Carmel, United States · NIH-11409867

• Predicting 2-year risk of age-related macular degeneration with AI

  A patient-friendly AI tool is being developed to predict who is at higher risk of developing late AMD within the next two years.

  NIH research Ihealthscreen, INC. · Richmond Hill, UNITED STATES · NIH-11399767

• Understanding how a protein called osteopontin affects aging eyes and dry age-related macular degeneration

  A researcher at Duke is studying how osteopontin, a protein involved in inflammation, may contribute to aging of the eye and the most common cause of vision loss in older adults.

  NIH research Duke University · Durham, United States · NIH-11384499

• Role of ARMS2 mutations in age-related macular degeneration

  This grant explores how ARMS2 genetic changes may drive age-related macular degeneration and how these changes cause AMD-related eye damage in mouse models.

  NIH research Jackson Laboratory · Bar Harbor, United States · NIH-11384282

• Metabolomics approach to uncover how age-related macular degeneration develops

  A patient-facing look at how we study small molecules in blood and eye tissue to understand why people develop AMD and how it progresses.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11380958

• OCT Angiography for Age-related Macular Degeneration

  A patient-friendly look at using advanced eye imaging to help diagnose and monitor age-related macular degeneration, with the goal of protecting vision.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11379944

• Role of Bruch Membrane Heparan Sulfate in Drusen Formation in Age-Related Macular Degeneration

  Researchers are studying how a sugar molecule on Bruch’s membrane may influence the buildup of drusen and progression of age-related macular degeneration to guide new treatments.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11374972

• Understanding how non-coding genetic risk affects AMD in the eye

  A study explores how non-coding genetic differences near the 10q26 region contribute to age-related macular degeneration and tests new therapeutic ideas.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11367610

• PLA2G2A's role in macular degeneration and potential new therapies

  A study at the University of Rochester will explore how a specific inflammatory enzyme, PLA2G2A, may drive age-related macular degeneration and whether targeting it could lead to new treatments.

  NIH research University of Rochester · Rochester, United States · NIH-11365167

• Predicting risk for macular degeneration and glaucoma using blood fats and machine learning

  A study will use blood fatty acids and machine learning to identify early signals of eye diseases like age-related macular degeneration and glaucoma using data from long-term health studies.

  NIH research Omegaquant Analytics, LLC · Sioux Falls, United States · NIH-11313903

• Gene therapy to protect vision in age-related macular degeneration

  A patient-focused gene therapy approach aims to slow or prevent progression of intermediate AMD to more advanced stages.

  NIH research Oculogenex · Dallas, UNITED STATES · NIH-11311499

• Complement Factor H–based Therapies for Age-Related Macular Degeneration

  A study aimed at developing therapies that modulate the immune system to slow or prevent vision loss in people with age-related macular degeneration.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11310756

• Efficient photostress recovery biomarkers for age-related macular degeneration

  A small NIH-funded project will test quick, easy biomarkers of how well people with age-related macular degeneration recover after light exposure to help track disease progression and treatment effects.

  NIH research Perzeption INC. · Littleton, UNITED STATES · NIH-11310564

• Maximizing Visual Potential for People with Age-Related Macular Degeneration

  This grant investigates how people with age-related macular degeneration adapt their eye movements and attention to use the best remaining vision to perform everyday tasks.

  NIH research Smith-Kettlewell Eye Research Institute · San Francisco, United States · NIH-11298071

• Rebuilding the blood–retina barrier to learn how APOE gene types affect macular degeneration

  Researchers will grow a human retinal tissue with blood-vessel channels to learn how different APOE gene types influence age-related macular degeneration in people.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11270833

• Humanin-like gene and mitochondrial health in age-related macular degeneration

  This project looks at a gene called MTRNR2L1 and how it affects the energy-making parts of eye cells in people with age-related macular degeneration.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11267232

• Inflammasome-driven inflammation in age-related macular degeneration

  This work looks at how two inflammation proteins, AIM2 and NLRP3, may cause or worsen wet age-related macular degeneration to help find better treatments for people with AMD.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11259425

• Dissecting retinal glial regulome to refine AMD risk genes and networks

  This project looks at how genetic and epigenetic changes in retinal glial cells contribute to age-related macular degeneration, with the goal of better understanding why some people develop AMD.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11224284

• Exercise program to help Veterans with age-related macular degeneration keep vision and daily function

  Veterans with intermediate age-related macular degeneration will join a 6-month online group spin cycling program to try to preserve vision, thinking, and everyday functioning.

  NIH research Veterans Health Administration · Decatur, UNITED STATES · NIH-11222659

• Ribozyme treatment to reduce toxic retinal pigments in dry macular degeneration

  This project will develop a ribozyme treatment to break down toxic pigments in the retina and help protect vision for people with dry age-related and juvenile macular degeneration.

  NIH research VA Western New York Healthcare System · Buffalo, United States · NIH-11218694

• Reducing harmful inflammation in wet age-related macular degeneration

  This project looks for ways to block damaging immune inflammation in people with neovascular (wet) age-related macular degeneration to help protect their vision.

  NIH research Yale University · New Haven, United States · NIH-11172498

• A transplant approach to repair sight loss from macular degeneration

  The project aims to replace damaged light-sensing cells and their supporting retinal cells to help people with dry age-related macular degeneration regain vision.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11166382

• Tool to predict your 2-year risk of late age-related macular degeneration

  This AI tool predicts whether people with early or intermediate age-related macular degeneration are likely to develop late AMD within two years.

  NIH research Ihealthscreen, INC. · Richmond Hill, UNITED STATES · NIH-11146532

• Improving Vision for Veterans with Macular Degeneration

  This project explores new ways to help Veterans with age-related macular degeneration regain some vision by teaching their brains to use touch more effectively.

  NIH research Charlie Norwood VA Medical Center · Augusta, United States · NIH-11144249

• Stopping abnormal blood vessel growth and scar tissue under the retina in wet age-related macular degeneration

  This project tests new drug approaches to prevent abnormal blood vessels and scarring under the retina in adults with neovascular (wet) age-related macular degeneration.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11142546

• A new approach to treat dry age-related macular degeneration

  This study is exploring a new treatment for dry age-related macular degeneration and juvenile macular degeneration by using special tools to help clear out harmful substances in the eye, with the hope of protecting and improving vision for those affected.

  NIH research VA Western New York Healthcare System · Buffalo, United States · NIH-11138540

• How sex affects mitochondrial and epigenetic factors in age-related vision loss.

  This study is looking at how being male or female might affect the way age-related macular degeneration (AMD) develops, especially in women over 60, to help find better treatments tailored to each person's needs.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11134035

• Measuring small molecules to better understand age-related macular degeneration

  This project will measure specific small molecules in people with age-related macular degeneration to find signals that predict progression.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11131651

• Osteopontin's role in aging eyes and macular degeneration

  This project looks at how a protein called osteopontin affects retinal cells in older adults and may contribute to dry age-related macular degeneration.

  NIH research Duke University · Durham, United States · NIH-11131110

• Non-leaky (Type 1) macular blood vessels and age-related macular degeneration

  This project looks at whether a quiet, non-leaking form of new blood vessels in the macula helps protect vision in people with age-related macular degeneration.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11123162

Related topics

Quick answers

How many Macular Degeneration clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in United States (11 trials), Spain (3 trials), China (3 trials), Czechia (2 trials), Hungary (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 3, Phase 1: 2, Phase 4: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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