Pro/renin receptor signaling and diabetic retinopathy
Official title: Pro/renin receptor-mediated signaling in pathogenesis of diabetic retinopathy
Funded at University of Florida · NIH-11399831 · Data updated 2026-11-12
A diabetes-related eye disease called diabetic retinopathy will be studied to understand how a specific protein pathway contributes to eye damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $381,250 |
| NIH project number | 5R01EY035413-04 |
| Project ID | NIH-11399831 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with diabetes at risk for or currently experiencing diabetic retinopathy may benefit from future therapies stemming from this research.
✕Less likely to help
Patients without diabetic retinopathy or those not eligible for future translational trials may not receive direct benefit.
What this research studies
This project looks at how the prorenin receptor and related signaling in the eye affect inflammation, oxidative stress, and retinal damage in diabetes. Researchers will examine how local eye-based renin-angiotensin system components influence disease progression, using animal models and molecular analysis. The goal is to uncover mechanisms that could lead to new treatments that protect vision for people with diabetes.
Why it matters
Potential benefit: If successful, the work could point to new ways to prevent or lessen vision loss in diabetic patients.
How similar studies have gone: Previous studies have linked renin-angiotensin system components to retinal damage, supporting the potential of this approach.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Li, Qiuhong — University of Florida
- Study coordinator: Li, Qiuhong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.