Understanding the causes of severe diabetic retinopathy
Molecular Mechanisms of Severe Diabetic Retinopathy
['FUNDING_R01'] · STATE UNIVERSITY OF NEW YORK AT BUFFALO · NIH-11190947
This study is looking into how a specific process in the eye can lead to serious vision problems for people with diabetes, and it hopes to find new ways to help prevent these issues for those affected by diabetic retinopathy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STATE UNIVERSITY OF NEW YORK AT BUFFALO (nih funded) |
| Locations | 1 site (AMHERST, UNITED STATES) |
| Trial ID | NIH-11190947 on ClinicalTrials.gov |
What this research studies
This research investigates the underlying mechanisms that lead to severe diabetic retinopathy, a condition that can cause blindness in working-age adults. The study focuses on a specific pathway involving NADPH oxidase 4 (Nox4), which is known to contribute to vascular damage in the retina. By examining how Nox4 affects retinal cells and leads to complications in diabetes, the research aims to identify potential long-term treatments to prevent the progression of this debilitating condition. Patients with diabetic retinopathy may benefit from insights gained through this research, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with diabetic retinopathy.
Not a fit: Patients without diabetes or those who do not have diabetic retinopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression of diabetic retinopathy and reduce the risk of blindness.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in diabetic retinopathy, indicating that this approach may lead to meaningful advancements.
Where this research is happening
AMHERST, UNITED STATES
- STATE UNIVERSITY OF NEW YORK AT BUFFALO — AMHERST, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, SARAH X — STATE UNIVERSITY OF NEW YORK AT BUFFALO
- Study coordinator: ZHANG, SARAH X
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.