Using advanced imaging to analyze retinal vascular diseases
Official title: Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease
Run by Johns Hopkins University · NCT04505618 · Data updated 2026-11-12
This study is testing new imaging techniques to see how they can help doctors understand and track the progress of retinal diseases like diabetic retinopathy in both healthy people and those affected by these conditions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 1050 (estimated) |
| Sponsor | Johns Hopkins University Academic / other |
| Locations | 1 site (Baltimore, Maryland) |
| Status | Recruiting |
| Started | October 1, 2019 |
| Main results expected | June 1, 2027 |
| Study ends | September 1, 2027 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT04505618 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults with retinal vascular diseases such as diabetic retinopathy or retinal vein occlusion, as well as healthy controls for comparison.
✕Probably not a fit
Patients with significant eye diseases, such as glaucoma or age-related macular degeneration, or those with a history of certain systemic conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study conducts a prospective, longitudinal analysis of clinical and imaging findings from both healthy individuals and those with retinal vascular diseases. It aims to define diagnostic imaging criteria that indicate changes in disease stage, including progression or regression of conditions like diabetic retinopathy and retinal vein occlusion. Participants will undergo non-invasive imaging procedures, such as Optical Coherence Tomography (OCT) and fundus imaging, to correlate these findings with clinical disease stages and visual acuity. The study will utilize data collected through standard-of-care methods at eye clinics.
Why it matters
Potential benefit: If successful, this study could enhance the diagnostic criteria for retinal vascular diseases, leading to improved patient management and treatment outcomes.
How similar studies have gone: Other studies utilizing advanced imaging techniques like OCT have shown promise in improving the understanding and management of retinal diseases.
Who can join: the full rules
Show full inclusion / exclusion criteria
Exclusion Criteria: * Both subjects with diseases and controls: * Children (age\<18) * Pregnant females * Developmentally delayed subjects * Subjects unable to provide informed consent * Inability to cooperate with tests and study instructions * Images with motion artifact or signal strength \< 7 * History of glaucoma * History of age-related macular degeneration * History of any visually significant eye disease * History of proliferative diabetic retinopathy * History of any inflammatory disease * History of heart disease * History of thyroid disease. * Additional criteria for controls: * History of any type of Diabetes Mellitus * History of any type of Hypertension
Where it's running
-
Wilmer Eye Institute
Baltimore, Maryland, United States Recruiting
Study contacts
- Principal investigator: Amir Kashani, MD, MPH — Johns Hopkins University
- Study coordinator: Amir H Kashani, MD, PhD
- Email: akashan1@jhmi.edu
- Phone: 410-502-2789
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.