Using stem cells to repair blood vessels in diabetic eye disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the potential of human inducible pluripotent stem cells (iPSCs) as a therapeutic option for diabetic retinopathy and macular ischemia. iPSCs will be derived from the blood of diabetic patients and healthy controls, and their ability to generate mesoderm cells will be tested in diabetic rodent and primate models. The focus is on assessing the capacity of these cells to form endothelial cells and pericytes in damaged blood vessels, as well as evaluating the combined effects of iPSC-derived hematopoietic cells on vascular repair. The ultimate goal is to enhance vessel formation and improve outcomes for patients with diabetic complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Any man or woman between the ages of 21- 98 years of age will be eligible to participate. To participate in the study as a study subject we will require: a) the subject must either carry the diagnosis of diabetes or be a healthy aged control and b) the patient be willing and have the ability to cooperate with the eye exam and skin punch biopsy protocol.

Exclusion Criteria:

* We will apply the following exclusion criteria: a) evidence of ongoing acute or chronic infection (HIV, Hepatitis B or C, tuberculosis); b) ongoing malignancy; c) cerebral vascular accident or cerebral vascular procedure; d) current pregnancy; e) history of organ transplantation; f) presence of a graft (to avoid any effect of the graft on inflammatory parameters; and g) patients with anemia. Subjects with AMD, glaucoma, uveitis, known hereditary degenerations or other significant ocular complications other than diabetic retinopathy will be excluded.

Where it's running

• University of Alabama at Birmingham
  Birmingham, Alabama, United States Recruiting

Study contacts

• Principal investigator: Maria B Grant, MD — 1954
• Study coordinator: Jennifer Moorer
• Email: jmoorer@uabmc.edu
• Phone: 205 325 8674

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.