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Clinical trial Recruiting at 3 sites Observational Ages 18 and up

Identifying a biomarker for diabetic retinopathy

Official title: Biomarker of Diabetic Retinopathy

Run by Indiana University · NCT05079399 · Data updated 2026-11-12

This study is trying to find a blood marker that can help show how healthy the eye blood vessels are in people with diabetic retinopathy.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment192 (estimated)
SponsorIndiana University
Academic / other
Locations3 sites (Carmel, Indiana and 2 other locations)
StatusRecruiting
StartedJanuary 1, 2022
Main results expectedJune 30, 2027
Study endsJune 30, 2027
Registry record updatedJuly 23, 2026
Trial IDNCT05079399 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals with established type 2 diabetes who have not undergone certain eye treatments.

Probably not a fit

Patients with a history of malignancy, acute infections, or other specified eye conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to discover a biomarker that indicates the health status of retinal blood vessels in patients with diabetic retinopathy, a common complication of diabetes. By analyzing specialized cells in the blood, researchers hope to find a reliable marker that can provide insights into the condition of the retina. Participants will undergo blood draws to facilitate this analysis. The study focuses on individuals with established type 2 diabetes who meet specific eligibility criteria.

Why it matters

Potential benefit: If successful, this study could lead to improved diagnosis and monitoring of diabetic retinopathy, enhancing patient care.

How similar studies have gone: While the approach of identifying biomarkers in diabetic retinopathy is being explored, this specific study's methodology is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Ability to cooperate with imaging procedures.
* Health status: established type 2 diabetes
* No history of panretinal photocoagulation (PRP)
* No history of treatment with intravitreal agents for past 12 months

Exclusion Criteria:

* Previous or current malignancy
* Acute or chronic infection (HIV, hepatitis B or C, tuberculosis)
* Cerebral vascular accident or cerebral vascular procedure
* Current pregnancy
* History of organ transplantation
* Presence of a graft (to avoid any effect of the graft)
* History of previous vitrectomy
* Subjects with a history of age-related macular degeneration age-related macular degeneration (AMD), glaucoma, uveitis, and branched or central vein occlusion.

Where it's running

  • Spring Mill Clinic
    Carmel, Indiana, United States     Recruiting
  • Eskenazi Eye Clinic
    Indianapolis, Indiana, United States     Recruiting
  • Glick Eye Institute
    Indianapolis, Indiana, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Diabetic Retinopathy 156Indiana University 158
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.