Retinal microvascular changes in diabetic retinopathy measured with OCTA
Official title: Assessment of Retinal Microvascular Changes by OCT Angiography and Their Correlation With Visual Acuity and Glycemic Control Across Different Stages of Diabetic Retinopathy
Run by Sohag University · NCT07747428 · Data updated 2026-11-12
This observational study tests how retinal blood vessel patterns seen on OCTA relate to vision and blood sugar control in adults with diabetic retinopathy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Sohag University Academic / other |
| Locations | 1 site (Sohag) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 5, 2026 |
| Trial ID | NCT07747428 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with diabetic retinopathy who can undergo OCTA imaging and have a recent HbA1c measurement.
✕Probably not a fit
Patients with media opacities or other excluded conditions that prevent high-quality OCTA imaging may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This cross-sectional study will use optical coherence tomography angiography (OCTA) to quantify retinal vessel density in the superficial and deep capillary plexuses and measure the foveal avascular zone in adults with diabetic retinopathy. Researchers will examine how these OCTA parameters correlate with best-corrected visual acuity and HbA1c levels across different retinopathy stages. The study is conducted at Sohag University’s Department of Ophthalmology and includes comprehensive ophthalmic exams, OCT, and OCTA imaging. Findings could clarify the relationship between microvascular changes and visual function in diabetic retinopathy.
Why it matters
Potential benefit: If successful, the study could improve understanding of how microvascular alterations relate to vision loss in diabetic retinopathy and guide future diagnostic or monitoring approaches.
How similar studies have gone: Previous research using OCTA has shown meaningful associations between retinal microvasculature and visual function in diabetic retinopathy, though this study adds a cross-sectional emphasis at a single institution.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Inclusion Criteria: * Adults aged 18 to 80 years. * Patients diagnosed with diabetic retinopathy. * Ability to undergo complete ophthalmic examination including OCT and OCT angiography. * Availability of HbA1c measurement within the study period. * Ability and willingness to provide written informed consent. Exclusion Criteria: * Previous vitreoretinal surgery. * Significant media opacity affecting image quality (e.g., dense cataract or vitreous hemorrhage). * Other retinal vascular diseases (e.g., retinal vein occlusion). * Glaucoma or optic nerve diseases affecting visual function. * High myopia (\>6 diopters). * Poor-quality OCTA images due to motion artifacts or poor fixation. * Refusal or inability to provide informed consent. Exclusion Criteria: \-
Where it's running
-
Sohag Ophthalmology Hospital
Sohag, Egypt Recruiting
Study contacts
- Study coordinator: Omnia Mohamed Abdel Aziz, M.B.BCh
- Email: 01011000347a@gmail.com
- Phone: 01011000347
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.