Biorepository for studying retinal diseases
Official title: NEI Intramural Biorepository for Retinal Diseases
Run by National Institutes of Health Clinical Center (CC) · NCT01496625 · Data updated 2026-11-12
This study is collecting health information and samples from people with and without eye diseases to see how these conditions develop and respond to treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years to 120 Years |
| Sex | All |
| Enrollment | 650 (estimated) |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Status | Recruiting |
| Started | June 18, 2012 |
| Registry record updated | October 26, 2026 |
| Trial ID | NCT01496625 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 2 years and older with diagnosed or undiagnosed retinal diseases, as well as healthy volunteers without any history of eye disease.
✕Probably not a fit
Patients who are unable or unwilling to provide informed consent or have systemic diseases that hinder adequate ophthalmologic examination may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to collect health information and biological samples from individuals with and without retinal diseases, including age-related macular degeneration and diabetic retinopathy. Researchers will follow participants over time to understand the nature of these eye diseases and identify genetic and environmental factors that contribute to their development and treatment responses. The study will establish a comprehensive database and biospecimen repository for future research on retinal conditions. Participants will undergo standardized testing and imaging, and their samples will be processed and stored for ongoing research.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment of retinal diseases, benefiting patients with these conditions.
How similar studies have gone: Other studies have successfully utilized biorepositories for similar retinal diseases, indicating a promising approach for understanding these conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: Participants will be eligible if they: * Have the ability to understand and sign an informed consent or have a parent/legal guardian to do so if they are minor children. * Manifest diagnosed or undiagnosed retinal disease(s), or could serve as an unaffected control suitable for comparison to participants with various retinal diseases, particularly AMD and diabetic retinopathy (taking into account matching factors such as age and past ocular history). EXCLUSION CRITERIA: Participants will not be eligible if they: * Are unable or unwilling to give informed consent that includes collection and study of at least one peripheral blood sample. * Are unable or unwilling to give informed consent that includes use of NIH medical records and clinical samples for research. * Have a systemic disease that compromises the ability to provide adequate ophthalmologic examination or treatment.
Where it's running
-
National Institutes of Health Clinical Center
Bethesda, Maryland, United States Recruiting
Study contacts
- Principal investigator: Tiarnan DL Keenan, M.D. — National Eye Institute (NEI)
- Study coordinator: Sheena Jose
- Email: sheena.jose@nih.gov
- Phone: (301) 402-7635
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Watching a short video before anti-VEGF eye injections
This trial will test whether watching a brief procedural video before a first anti-VEGF intravitreal injection helps people with retinal diseases feel less anxious and have fewer or smaller subconjunctival hemorrhages.
-
Hyperspectral imaging to map retinal and optic nerve structures
This study will test whether hyperspectral retinal imaging can detect disease-related features in adults with diabetic retinopathy, glaucoma, age-related macular degeneration, and in healthy volunteers.
-
Tracking retinal changes over two years in people with moderate to early proliferative diabetic retinopathy
This project will try to find imaging, functional, and blood markers that show whether retinopathy is getting worse over two years in people with type 2 diabetes and moderate-to-mildly advanced disease.
-
High Resolution Imaging OCT Study
This study tests whether two investigational OCT devices (R1 and HighRes OCT) produce better image quality than the standard Spectralis in adults with normal eyes or with AMD, diabetic retinopathy, or other retinal diseases.
-
Vision screening in general practice to catch preventable sight loss in people over 70
This project will test a GP-based vision-screening program for people aged 70 and older with at least one chronic condition to find sight problems early.
-
Improving follow-up after an eye screening referral
This trial tries text message or health worker reminders to help people referred after an eye screening get to their hospital appointment within 21 days.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.