Biorepository for studying retinal diseases
NEI Intramural Biorepository for Retinal Diseases
This study is collecting health information and samples from people with and without eye diseases to see how these conditions develop and respond to treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 650 (estimated) |
| Ages | 2 Years to 120 Years |
| Sex | All |
| Sponsor | National Institutes of Health Clinical Center (CC) NIH |
| Locations | 1 site (Bethesda, Maryland) |
| Trial ID | NCT01496625 on ClinicalTrials.gov |
What this trial studies
This study aims to collect health information and biological samples from individuals with and without retinal diseases, including age-related macular degeneration and diabetic retinopathy. Researchers will follow participants over time to understand the nature of these eye diseases and identify genetic and environmental factors that contribute to their development and treatment responses. The study will establish a comprehensive database and biospecimen repository for future research on retinal conditions. Participants will undergo standardized testing and imaging, and their samples will be processed and stored for ongoing research.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 2 years and older with diagnosed or undiagnosed retinal diseases, as well as healthy volunteers without any history of eye disease.
Not a fit: Patients who are unable or unwilling to provide informed consent or have systemic diseases that hinder adequate ophthalmologic examination may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment of retinal diseases, benefiting patients with these conditions.
How similar studies have performed: Other studies have successfully utilized biorepositories for similar retinal diseases, indicating a promising approach for understanding these conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
* INCLUSION CRITERIA: Participants will be eligible if they: * Have the ability to understand and sign an informed consent or have a parent/legal guardian to do so if they are minor children. * Manifest diagnosed or undiagnosed retinal disease(s), or could serve as an unaffected control suitable for comparison to participants with various retinal diseases, particularly AMD and diabetic retinopathy (taking into account matching factors such as age and past ocular history). EXCLUSION CRITERIA: Participants will not be eligible if they: * Are unable or unwilling to give informed consent that includes collection and study of at least one peripheral blood sample. * Are unable or unwilling to give informed consent that includes use of NIH medical records and clinical samples for research. * Have a systemic disease that compromises the ability to provide adequate ophthalmologic examination or treatment.
Where this trial is running
Bethesda, Maryland
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States (Recruiting)
Study contacts
- Principal investigator: Tiarnan DL Keenan, M.D. — National Eye Institute (NEI)
- Study coordinator: Sheena Jose
- Email: sheena.jose@nih.gov
- Phone: (301) 402-7635
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.