Characterizing diabetes and obesity in Greenlandic patients
Phenotypic and Genotypic Characterization of Patients With Dysmetabolism in Greenland
NA · Steno Diabetes Center Greenland · NCT06264427
This study is trying to learn more about how genetics and environment affect type 2 diabetes and obesity in Greenlandic people, while also looking at related health issues like sleep apnea.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Steno Diabetes Center Greenland (other) |
| Locations | 1 site (Nuuk, Sermersooq) |
| Trial ID | NCT06264427 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to explore the phenotypic and genotypic characteristics of individuals with type 2 diabetes and severe obesity in Greenland. It focuses on understanding the unique genetic and environmental interactions that influence disease progression in the Greenlandic Inuit population. The study employs whole genome sequencing to identify specific genetic variants linked to insulin resistance and maturity-onset diabetes, while also assessing the prevalence of obstructive sleep apnea among high-risk individuals. Participants will undergo clinical evaluations and complete questionnaires to provide insights into their quality of life and functional outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old with type 2 diabetes and/or morbid obesity (BMI > 40).
Not a fit: Patients who do not speak English, Danish, or Greenlandic will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved personalized treatment strategies for diabetes and obesity in the Greenlandic population.
How similar studies have performed: While similar studies have explored genetic factors in diabetes, this specific focus on the Greenlandic Inuit population and their unique genetic and environmental context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Type 2 diabetes and/or morbid obesity (BMI \>40) * Over 18 years old Exclusion Criteria: * Does not speak either English, Danish or Greenlandic
Where this trial is running
Nuuk, Sermersooq
- Steno Diabetes Center Greenland, Queen Ingrids Hospital — Nuuk, Sermersooq, Greenland (RECRUITING)
Study contacts
- Principal investigator: Marit Eika Jørgensen, Md. Phd — Steno Diabetes Center Greenland
- Study coordinator: Mads Jensen, MD.
- Email: MMSN@peqqik.gl
- Phone: +299 34 46 23
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Diabetes Mellitus, Type 2, Obesity, Morbid, Obstructive Sleep Apnea, MODY, Diabetic Retinopathy, Diabetic Neuropathies