Understanding how brain cells contribute to major depressive disorder
The role of microglia in major depressive disorder
This study is looking at how certain brain cells might be involved in major depressive disorder to help understand the condition better and find new ways to treat it for people who are struggling with depression.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10948932 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, a type of brain cell, in major depressive disorder (MDD), which affects millions worldwide. The study aims to uncover the biological mechanisms behind MDD by linking genetic risk factors to changes in gene expression in brain tissues. By utilizing advanced techniques like massively parallel reporter assays, researchers will validate how specific genetic variants influence the activity of genes related to depression. This approach could lead to new therapeutic strategies for those suffering from MDD.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of major depressive disorder.
Not a fit: Patients with depression who are under 21 years old or those whose symptoms are not linked to biological factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for major depressive disorder, improving the quality of life for many patients.
How similar studies have performed: Other research has shown success in linking genetic risk factors to psychiatric disorders, suggesting that this approach may yield valuable insights for major depressive disorder as well.
Where this research is happening
Bronx, United States
- James J Peters VA Medical Center — Bronx, United States (Active)
Researchers
- Principal investigator: Dracheva, Stella — James J Peters VA Medical Center
- Study coordinator: Dracheva, Stella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.