Temporal interference stimulation for depressive disorder

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Thirty adults with DSM‑5 diagnosed depressive disorder will receive either a 30‑minute session of temporal interference stimulation (TIS) or a sham TIS, with thirty matched healthy controls included for comparison. Participants complete neuropsychological assessments (including HAMD, HAMA, PHQ‑15, BSSI, PSQI, RRS, and others) and multimodal MRI (3D‑T1, resting‑state fMRI, and DTI) before and after the intervention. An incidental memory task using emotional pictures is used to measure associative memory changes pre‑ and post‑treatment. Clinical and imaging measures are compared between active and sham stimulation groups and against healthy controls.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* the patients were diagnosed by more than 2 psychiatrists and met the diagnostic criteria of DSM-5 for depression, and HAMD\>17, BSS\>6, PHQ-15\>5.
* the age ranged from 18 to 65 years old, and the length of education was more than 5 years.
* the visual acuity or corrected visual acuity is normal, right-handed, can cooperate with the completion of various experimental tests.

Exclusion Criteria:

* accompanied by severe somatic diseases, such as severe heart, liver, renal insufficiency and so on.
* accompanied by other neurological diseases, such as stroke, epilepsy and so on. pregnant and lactating women.
* accompanied by other mental disorders, such as drug abuse, schizophrenia, schizophrenic affective

Where it's running

• Anhui Medical University
  Hefei, Anhui, China Recruiting
• Anhui Mental Health Center
  Hefei, Anhui, China Recruiting

Study contacts

• Study coordinator: Yanghua Tian, PhD
• Email: zylykd@163.com
• Phone: 0551 6599 7278

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.