Investigating how microRNAs affect major depressive disorder
Official title: Assessing miRNA expression in the Corticolimbic System of Major Depressive Disorder
Funded at University of Arizona · NIH-10893026 · Data updated 2026-11-12
This study is looking at tiny molecules in the brain that might help explain why some people experience major depressive disorder, with the hope of finding new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | April 1, 2019 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $600,522 |
| NIH project number | 5R01MH118239-05 |
| Project ID | NIH-10893026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with major depressive disorder.
✕Less likely to help
Patients with other psychiatric disorders that do not involve major depressive disorder may not benefit from this research.
What this research studies
This research aims to explore the role of microRNAs (miRNAs) in major depressive disorder (MDD) by analyzing their expression in the corticolimbic system of the brain. Using a large collection of postmortem brain samples, the study will employ miRNA sequencing to identify how these molecules influence gene expression related to MDD. By understanding these biological mechanisms, the research seeks to uncover potential targets for new treatments. Patients with MDD may find this research particularly relevant as it addresses the underlying genetic factors contributing to their condition.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating major depressive disorder.
How similar studies have gone: Previous research has shown promising results in understanding the role of genetic factors in psychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Vladimirov, Vladimir Ivanov — University of Arizona
- Study coordinator: Vladimirov, Vladimir Ivanov
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.