Identifying different types of major depressive disorder using data analysis
Official title: Data-driven subtyping in major depressive disorder
Funded at Massachusetts General Hospital · NIH-10808944 · Data updated 2026-11-12
This study is looking at different types of major depressive disorder to find better ways to treat people who haven't had success with usual therapies, so they can get more personalized and effective help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 16, 2021 |
| Project end | February 28, 2026 |
| Funding year | 2024 |
| Award (this year) | $811,567 |
| NIH project number | 5R01MH123804-04 |
| Project ID | NIH-10808944 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with major depressive disorder, particularly those who have not responded well to standard treatments.
✕Less likely to help
Patients with mild depressive symptoms or those who do not meet the criteria for major depressive disorder may not benefit from this research.
What this research studies
This research investigates how to better classify major depressive disorder (MDD) by analyzing large electronic health record datasets. By identifying distinct subtypes of depression, the study aims to improve treatment strategies and outcomes for patients who do not respond to standard therapies. The approach combines advanced data engineering techniques to create interpretable features that can help predict treatment responses. This could lead to more personalized and effective treatment options for individuals suffering from MDD.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatment options for patients with major depressive disorder.
How similar studies have gone: Previous research in other medical conditions has shown that identifying subtypes can lead to significant therapeutic advancements, suggesting a promising potential for this approach in major depressive disorder.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Perlis, Roy H. — Massachusetts General Hospital
- Study coordinator: Perlis, Roy H.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.