Evaluating the effects of electroconvulsive therapy on depression
Official title: Acute Efficacy and 6 Months Follow up After Electroconvulsive Therapy for Severe or Treatment Resistant Depression - Predictors of Response, Side Effects, and Relapse
Run by Haukeland University Hospital · NCT05388461 · Data updated 2026-11-12
This study is testing how electroconvulsive therapy can help people with major depression feel better and what effects it might have on their thinking over six months.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 600 (estimated) |
| Sponsor | Haukeland University Hospital Academic / other |
| Locations | 2 sites (Bergen and 1 other locations) |
| Status | Recruiting |
| Started | March 13, 2013 |
| Main results expected | December 2028 |
| Study ends | December 2028 |
| Registry record updated | September 26, 2023 |
| Trial ID | NCT05388461 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with major depression who are receiving ECT at Haukeland University Hospital or Stavanger University Hospital.
✕Probably not a fit
Patients receiving ECT for indications other than major depression or those who do not consent to participate will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to assess both the immediate and long-term outcomes of electroconvulsive therapy (ECT) in patients with major depressive disorder. Patients referred for ECT will be enrolled in a research registry after providing written consent. The study will evaluate depressive symptoms and cognitive function through clinician and patient-rated measures, identifying factors that predict response, remission, side effects, and relapse over a six-month period. Additionally, the duration of potential cognitive impairment and predictors of cognitive outcomes will be examined.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the efficacy and safety of ECT for treating major depression.
How similar studies have gone: Other studies have shown varying degrees of success with ECT for depression, but this specific approach of assessing both acute and long-term outcomes in a non-selected cohort is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients treated with ECT for major depression (F31.3-5, F32, F33) at Haukeland University Hospital or Stavanger University Hospital after 2013, * written consent to enrolment into the Regional Register for neurostimulation. Exclusion Criteria: * ECT performed on other indications than major depression. * No consent to the register.
Where it's running
-
Haukeland University Hospital
Bergen, Norway Recruiting -
Stavanger University Hospital
Stavanger, Norway Recruiting
Study contacts
- Study coordinator: Ute Kessler, PhD
- Email: ute.kessler@helse-bergen.no
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.