Clinical trial Recruiting at 2 sites Observational Ages 18 and up

Evaluating the effects of electroconvulsive therapy on depression

Official title: Acute Efficacy and 6 Months Follow up After Electroconvulsive Therapy for Severe or Treatment Resistant Depression - Predictors of Response, Side Effects, and Relapse

Run by Haukeland University Hospital · NCT05388461 · Data updated 2026-11-12

This study is testing how electroconvulsive therapy can help people with major depression feel better and what effects it might have on their thinking over six months.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment600 (estimated)
SponsorHaukeland University Hospital
Academic / other
Locations2 sites (Bergen and 1 other locations)
StatusRecruiting
StartedMarch 13, 2013
Main results expectedDecember 2028
Study endsDecember 2028
Registry record updatedSeptember 26, 2023
Trial IDNCT05388461 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients diagnosed with major depression who are receiving ECT at Haukeland University Hospital or Stavanger University Hospital.

Probably not a fit

Patients receiving ECT for indications other than major depression or those who do not consent to participate will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to assess both the immediate and long-term outcomes of electroconvulsive therapy (ECT) in patients with major depressive disorder. Patients referred for ECT will be enrolled in a research registry after providing written consent. The study will evaluate depressive symptoms and cognitive function through clinician and patient-rated measures, identifying factors that predict response, remission, side effects, and relapse over a six-month period. Additionally, the duration of potential cognitive impairment and predictors of cognitive outcomes will be examined.

Why it matters

Potential benefit: If successful, this study could provide valuable insights into the efficacy and safety of ECT for treating major depression.

How similar studies have gone: Other studies have shown varying degrees of success with ECT for depression, but this specific approach of assessing both acute and long-term outcomes in a non-selected cohort is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients treated with ECT for major depression (F31.3-5, F32, F33) at Haukeland University Hospital or Stavanger University Hospital after 2013,
* written consent to enrolment into the Regional Register for neurostimulation.

Exclusion Criteria:

* ECT performed on other indications than major depression.
* No consent to the register.

Where it's running

  • Haukeland University Hospital
    Bergen, Norway
    Recruiting
  • Stavanger University Hospital
    Stavanger, Norway
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.