Evaluating the effects of electroconvulsive therapy on depression
Acute Efficacy and 6 Months Follow up After Electroconvulsive Therapy for Severe or Treatment Resistant Depression - Predictors of Response, Side Effects, and Relapse
Haukeland University Hospital · NCT05388461
This study is testing how electroconvulsive therapy can help people with major depression feel better and what effects it might have on their thinking over six months.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Haukeland University Hospital (other) |
| Locations | 2 sites (Bergen and 1 other locations) |
| Trial ID | NCT05388461 on ClinicalTrials.gov |
What this trial studies
This project aims to assess both the immediate and long-term outcomes of electroconvulsive therapy (ECT) in patients with major depressive disorder. Patients referred for ECT will be enrolled in a research registry after providing written consent. The study will evaluate depressive symptoms and cognitive function through clinician and patient-rated measures, identifying factors that predict response, remission, side effects, and relapse over a six-month period. Additionally, the duration of potential cognitive impairment and predictors of cognitive outcomes will be examined.
Who should consider this trial
Good fit: Ideal candidates include patients diagnosed with major depression who are receiving ECT at Haukeland University Hospital or Stavanger University Hospital.
Not a fit: Patients receiving ECT for indications other than major depression or those who do not consent to participate will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into the efficacy and safety of ECT for treating major depression.
How similar studies have performed: Other studies have shown varying degrees of success with ECT for depression, but this specific approach of assessing both acute and long-term outcomes in a non-selected cohort is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients treated with ECT for major depression (F31.3-5, F32, F33) at Haukeland University Hospital or Stavanger University Hospital after 2013, * written consent to enrolment into the Regional Register for neurostimulation. Exclusion Criteria: * ECT performed on other indications than major depression. * No consent to the register.
Where this trial is running
Bergen and 1 other locations
- Haukeland University Hospital — Bergen, Norway (RECRUITING)
- Stavanger University Hospital — Stavanger, Norway (RECRUITING)
Study contacts
- Study coordinator: Ute Kessler, PhD
- Email: ute.kessler@helse-bergen.no
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Depressive Disorder