Condition

Bipolar Disorder (BD) clinical trials and research

• 27Clinical trials
• 3New in 30 days
• 11Countries

Newest Bipolar Disorder (BD) clinical trials

All recruiting trials (27)

• Affective Cognitive Training for mood disorders and their close relatives

  A six-week program combining virtual reality and computer exercises tests whether affective cognitive training helps people with mood disorders and their unaffected first-degree relatives.

  Recruiting Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital · Frederiksberg, Capital Region of Denmark · NCT07920302

• Understanding anxiety, depression, and bipolar disorder over time in China

  This study tests how anxiety, depressive, and bipolar symptoms change over three years to find patterns that help with earlier recognition and prediction in people aged 12–55.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07903246

• French Minds: a French, Multimodal Cohort Study of Severe Psychiatric Disorders and Healthy Controls

  This study tests whether people with mood, psychotic, or autism disorders can be grouped into more similar subtypes based on social withdrawal and anhedonia, across ages 15 to 60.

  Recruiting at 10 sites Fondation FondaMental · Besançon and 16 other locations · NCT07881016

• Predicting Treatment Response in Psychiatric Disorders Using Biological Markers

  This study tests whether biological markers can predict which patients with psychiatric conditions will respond to treatment.

  Recruiting Centre Hospitalier St Anne · Paris · NCT07741981

• Customized brain stimulation to help mood in bipolar disorder

  This study tests whether personalized, non-invasive brain stimulation with rTMS can help people with bipolar depression see if their mood shifts toward euthymia.

  Recruiting Phase 4 Weill Medical College of Cornell University · New York, New York · NCT07680153

• Pramipexole adds on to mood stabilizers for bipolar depression

  This trial tests whether adding pramipexole to standard mood-stabilizing treatment helps reduce anhedonia in adults with bipolar depression compared to a placebo.

  Recruiting Phase 3 Region Skane · Lund, Skåne County · NCT07664852

• FOCUS Bipolar: Families Opening Conversations for Understanding Signs

  This project tests a family-centered screening approach to help identify early signs of bipolar disorder in youth who have a parent with bipolar disorder.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT07622927

• Flumazenil to help reduce cognitive side effects during ECT for depression

  This study tests whether giving flumazenil to reverse benzodiazepine effects during electroconvulsive therapy can lower cognitive side effects without reducing treatment effectiveness in adults with depression.

  Recruiting Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital · Frederiksberg, Capital Region · NCT07619092

• Targeted brain stimulation to help metabolic issues in people with bipolar disorder and obesity

  This study tests a brain stimulation approach called temporal interference stimulation to see if it can improve metabolism and stability in adults with bipolar disorder and obesity.

  Recruiting First Affiliated Hospital of Zhejiang University · Hangzhou, Zhejiang · NCT07589647

• Predicting bipolar disorder relapse risk with multi-modal sentiment analysis

  This project tests whether combining speech, facial, and other emotional signals can help predict relapse risk in adults with bipolar disorder.

  Recruiting Shanghai Mental Health Center · Shanghai · NCT07573839

• Ketamine with DBT for suicidality in adults with treatment-resistant depression or bipolar disorder and BPD

  This study tests whether four ketamine infusions plus Dialectical Behavioural Therapy can more quickly reduce suicidal thoughts in adults with Borderline Personality Disorder and treatment-resistant depression or bipolar disorder.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT07569198

• Home-use brain stimulation for bipolar depression

  This trial will test whether a home-use tDCS headset can reduce depressive symptoms in adults with bipolar disorder compared with a placebo (sham) device.

  Recruiting King's College London · London · NCT07556692

• Using an epigenetic drug to boost virtual reality cognitive training for middle-aged and older adults with depression or bipolar disorder

  This trial will test whether daily sodium butyrate combined with three weeks of virtual reality cognitive training improves thinking skills in symptomatically stable adults aged 40–75 with depression or bipolar disorder.

  Recruiting Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital · Frederiksberg, Capital Region of Denmark · NCT07404085

• Romanian adaptation of the 6-item Hypomanic Personality Scale (HPS-6)

  This project will test the six-item Hypomanic Personality Scale in Romanian-speaking adults to see if it reliably screens for hypomanic traits.

  Recruiting Phase 1/2 Babes-Bolyai University · Cluj-Napoca · NCT07399626

• See if Borderline Personality Disorder can be viewed as a Relationship-Use Disorder

  Researchers are testing whether BPD symptoms reflect an addiction-like reliance on interpersonal relationships, compared with bipolar disorder and healthy controls.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07337889

• Effects of schizophrenia and bipolar disorder on breathing, exercise ability, and quality of life

  This project will see how schizophrenia and bipolar disorder relate to breathing strength, lung function, exercise capacity, and quality of life in adults.

  Recruiting Çankırı Karatekin University · Çankırı, Çankırı · NCT07306468

• Mapping complex cognitive problems across psychiatric and neurological conditions

  This project will test a set of cognitive tests and optional brain recordings in adults with psychiatric or neurological disorders and healthy volunteers to map high-level thinking problems and how they change over time.

  Recruiting at 2 sites Centre Hospitalier St Anne · Paris and 2 other locations · NCT07295652

• Multimodal phenotyping in adolescents hospitalized for depression

  This project will collect brain scans, blood tests, sleep and activity signals, and psychological test results from hospitalized teens with major depressive episodes to try to find patterns that predict treatment response and cognitive or emotional problems.

  Recruiting Jiangsu Province Nanjing Brain Hospital · Nanjing, Jiangsu · NCT07247344

• PEDAL: a group program with digital tools to help bipolar patients manage mood swings

  A group-based program for people with bipolar disorder tests a psychoeducation approach enhanced with digital resources to help manage affective lability.

  Recruiting at 4 sites Phase 2 Oslo University Hospital · Drammen and 3 other locations · NCT07239778

• Support program to help people with bipolar disorder transition from hospital to the community

  This pilot will try a combined program of group psychoeducation, one-on-one peer support, and clinician-focused help to see if it improves post-discharge outcomes for young adults (18–35) recently diagnosed with bipolar disorder who have had psychosis or limited illness insight.

  Recruiting McMaster University · Hamilton, Ontario · NCT07213492

• Time Restricted Eating in Bipolar Disorder and Obesity

  A randomized trial tests whether an 8-hour time-restricted eating plan helps adults with bipolar disorder who are overweight and mildly depressed compare to a wait-list control.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07211217

• Real-life lithium use in people with bipolar disorder

  This project will track daily lithium-taking patterns in adults with bipolar disorder using a smart pill box that timestamps removals plus weekly phone check-ins.

  Recruiting University of Aarhus · Aarhus · NCT07167563

• Blood biomarker plus questionnaire test to help diagnose bipolar disorder

  This trial will test whether a blood-based biomarker algorithm combined with the Mood Disorder Questionnaire (MDQ) can accurately identify adults with bipolar disorder who are currently experiencing a major depressive episode in primary care.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07031817

• Ketogenic diet for treating bipolar disorder in adolescents

  This study is testing if a ketogenic diet can help teenagers and young adults with bipolar disorder feel better when combined with their usual medications.

  Recruiting at 2 sites University of California, Los Angeles · Los Angeles, California and 3 other locations · NCT06920940

• Precision treatment strategies for common mental disorders

  This study is testing a personalized approach to treating common mental health conditions like depression and schizophrenia by using genetic information to help choose the right medications for people.

  Recruiting Peking University · Beijing, Beijing Municipality · NCT06729541

• GlobalMinds: a global genetic and health-record database to improve personalized care for people with serious mental illness and dementia

  This project will collect whole-genome data and linked health records from 50,000 adults with major mental illnesses or dementia to see if combining genetic and clinical information can help personalize diagnosis and treatment.

  Recruiting Akrivia Health · Oxford, Oxford · NCT06641726

• Program to lower cardiovascular risk with a nutrition plan for people with bipolar disorder

  This trial will test whether a dietary program based on the Brazilian Dietary Guidelines can lower cardiovascular risk in adults with bipolar disorder who are on stable medication.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT06488573

Related topics

Quick answers

How many Bipolar Disorder (BD) clinical trials are recruiting right now?

27, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in France (5 trials), China (5 trials), Denmark (4 trials), United States (4 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 3: 1, Phase 4: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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