Mapping complex cognitive problems across psychiatric and neurological conditions
Characterization of High-level Cognitive Impairments in Patients With Neuropsychiatric Disorders
NA · Centre Hospitalier St Anne · NCT07295652
This project will test a set of cognitive tests and optional brain recordings in adults with psychiatric or neurological disorders and healthy volunteers to map high-level thinking problems and how they change over time.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 600 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier St Anne (other) |
| Locations | 3 sites (Paris and 2 other locations) |
| Trial ID | NCT07295652 on ClinicalTrials.gov |
What this trial studies
The project will build a multidimensional, transdiagnostic atlas of high-level cognitive impairments by testing adults with a range of psychiatric and neurological diagnoses alongside healthy volunteers. Cognitive testing will be combined with optional MRI, EEG, and MEG to link behavioral profiles with brain measures. Tests will be iteratively refined to be shorter, more ergonomic, and suitable for digital platforms based on participant feedback and interim analyses. Repeated evaluations are planned to track changes with clinical course and routine treatments.
Who should consider this trial
Good fit: Adults over 18 with a diagnosed psychiatric disorder (e.g., schizophrenia, bipolar, depressive, ASD, OCD) or a diagnosed neurological disorder (e.g., neurodegenerative disease, focal lesion, epilepsy) who can give informed consent and attend in-person visits are ideal candidates.
Not a fit: People unable to complete cognitive testing due to severe motor or sensory impairment, those with active substance use disorder (except tobacco), or with unstable acute medical or psychiatric conditions are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the work could produce shorter, more usable digital tests and brain markers that help clinicians track cognitive problems and tailor care.
How similar studies have performed: Previous studies have characterized domain-specific cognitive deficits and linked them to brain measures, but a large transdiagnostic, high-level cognitive atlas combined with adaptive digital tests and multimodal neuroimaging remains relatively novel and not yet established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For patients: * Aged over 18 years * Diagnosed with a psychiatric disorder according to ICD-10 by a psychiatrist (F10-F98) or diagnosed with a neurological disorder according to ICD-10 by a neurologist (G00-G99) * Provided written informed consent * Affiliated with a social security scheme For healthy volunteers: * Aged over 18 years * Provided written informed consent * Affiliated with a social security scheme Exclusion Criteria: For healthy volunteers: * Current diagnosis of a psychiatric disorder according to ICD-10 (F20-F98) or current prescription of a psychotropic medication, or diagnosis of a neurological disorder according to ICD-10 (G00-G99) * History of depression (F32) * Substance use disorder (excluding tobacco) * Neurological history (e.g., stroke, coma, epilepsy, neuroinflammatory or neurodegenerative disease) or identified cognitive disorder * Inability to complete cognitive testing (e.g., due to motor or sensory impairment) For participants undergoing MRI (without contrast agent): * Presence of MRI contraindications: non-MRI-compatible pacemaker, heart valve, implant, or metallic foreign body * Pregnancy at the time of MRI
Where this trial is running
Paris and 2 other locations
- Departement of Adult Psychiatry, GH Pitié Salpétrière — Paris, France (RECRUITING)
- Groupe hospitalo-universitaire Paris Psychiatrie et Neurosciences — Paris, France (RECRUITING)
- Hôpital Fondation Adolphe de Rothschild — Paris, France (NOT_YET_RECRUITING)
Study contacts
- Principal investigator: Pierre BOURDILLON, Dr — Hôpital Fondation Adolphe de Rothschild
- Study coordinator: Jacob DHOTE, Dr
- Email: j.dhote@ghu-paris.fr
- Phone: +33 145658177
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Neurologic Disorders, Schizophrenia, Bipolar Disorder, Depressive Disorder, Cognitive dysfunction, Executive function, Metacognition, Motivation