Mapping complex cognitive problems across psychiatric and neurological conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The project will build a multidimensional, transdiagnostic atlas of high-level cognitive impairments by testing adults with a range of psychiatric and neurological diagnoses alongside healthy volunteers. Cognitive testing will be combined with optional MRI, EEG, and MEG to link behavioral profiles with brain measures. Tests will be iteratively refined to be shorter, more ergonomic, and suitable for digital platforms based on participant feedback and interim analyses. Repeated evaluations are planned to track changes with clinical course and routine treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For patients:

* Aged over 18 years
* Diagnosed with a psychiatric disorder according to ICD-10 by a psychiatrist (F10-F98) or diagnosed with a neurological disorder according to ICD-10 by a neurologist (G00-G99)
* Provided written informed consent
* Affiliated with a social security scheme

For healthy volunteers:

* Aged over 18 years
* Provided written informed consent
* Affiliated with a social security scheme

Exclusion Criteria:

For healthy volunteers:

* Current diagnosis of a psychiatric disorder according to ICD-10 (F20-F98) or current prescription of a psychotropic medication, or diagnosis of a neurological disorder according to ICD-10 (G00-G99)
* History of depression (F32)
* Substance use disorder (excluding tobacco)
* Neurological history (e.g., stroke, coma, epilepsy, neuroinflammatory or neurodegenerative disease) or identified cognitive disorder
* Inability to complete cognitive testing (e.g., due to motor or sensory impairment)

For participants undergoing MRI (without contrast agent):

* Presence of MRI contraindications: non-MRI-compatible pacemaker, heart valve, implant, or metallic foreign body
* Pregnancy at the time of MRI

Where it's running

• Departement of Adult Psychiatry, GH Pitié Salpétrière
  Paris, France Recruiting
• Groupe hospitalo-universitaire Paris Psychiatrie et Neurosciences
  Paris, France Recruiting
• Hôpital Fondation Adolphe de Rothschild
  Paris, France Not yet recruiting

Study contacts

• Principal investigator: Pierre BOURDILLON, Dr — Hôpital Fondation Adolphe de Rothschild
• Study coordinator: Jacob DHOTE, Dr
• Email: j.dhote@ghu-paris.fr
• Phone: +33 145658177

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Understanding anxiety, depression, and bipolar disorder over time in China

  This study tests how anxiety, depressive, and bipolar symptoms change over three years to find patterns that help with earlier recognition and prediction in people aged 12–55.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07903246

• Predicting Treatment Response in Psychiatric Disorders Using Biological Markers

  This study tests whether biological markers can predict which patients with psychiatric conditions will respond to treatment.

  Recruiting Centre Hospitalier St Anne · Paris · NCT07741981

• Using Lumateperone to improve motivation in patients with schizophrenia and psychosis

  This study is testing if Lumateperone can help people with schizophrenia or schizoaffective disorders feel more motivated and less apathetic.

  Recruiting Phase 3 Louisiana State University Health Sciences Center Shreveport · Shreveport, Louisiana · NCT06482554

• Examining the effects of combined therapy for schizophrenia

  This study is testing whether combining two therapies, one for managing thoughts and another for improving cognitive skills, can help people with schizophrenia do better in their daily lives compared to using just one of the therapies.

  Recruiting at 2 sites University of Toronto · Scarborough Village, Ontario and 1 other locations · NCT05731414

• Affective Cognitive Training for mood disorders and their close relatives

  A six-week program combining virtual reality and computer exercises tests whether affective cognitive training helps people with mood disorders and their unaffected first-degree relatives.

  Recruiting Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital · Frederiksberg, Capital Region of Denmark · NCT07920302

• XEP527 in stable schizophrenia: safety and how it behaves in the body

  This small, early-stage study tests the safety and how XEP527 behaves in people with stable schizophrenia who are on a single antipsychotic.

  Recruiting Phase 1 Novartis · Bentonville, Arkansas · NCT07908680

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.